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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Microenvironment in Primary Liver Cancer

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 28 Jun 2024 | 5 articles | Viewed by 11339 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Stereotactic Ablative Radiotherapy in the Management of Localized and Metastatic Genitourinary Tumours

edited by Stefano Arcangeli,

Giulia Marvaso

and

Denis Panizza

submission deadline 29 Jun 2024 | 2 articles | Viewed by 4124 | Submission Open

Keywords: stereotactic body radiation therapy (SBRT); image-guided radiation therapy (IGRT); imaging; prostate cancer; kidney cancer; motion management; oligometastases; androgen deprivation therapy (ADT); targeted therapy; immunotherapy; toxicity

(This special issue belongs to the Section Cancer Therapy)

Feature Review for Cancer Therapy

edited by

Robert Kleszcz

and

Jarosław Paluszczak

submission deadline 30 Jun 2024 | 10 articles | Viewed by 24110 | Submission Open

Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials

(This special issue belongs to the Section Cancer Therapy)

Concepts to Improve Targeted Radionuclide Therapy in Cancer: Ligand Design Optimization and Application of Emerging Radionuclides and Combination Therapies

edited by

Cristina Müller

submission deadline 30 Jun 2024 | 7 articles | Viewed by 19625 | Submission Open

Keywords: radionuclide therapy; nonstandard radionuclides; linker modification; albumin binders; small-molecule radioligands; radiopeptides; radiosensitizers; combination therapies; 3D in vitro systems; tumor mouse models

(This special issue belongs to the Section Cancer Therapy)

Current Progress in Proton Radiotherapy of Cancer

edited by

Carla Hajj

submission deadline 30 Jun 2024 | 9 articles | Viewed by 14606 | Submission Open

Keywords: proton; safety; efficacy; motion management; radiobiology; physics; planning; dosimetry; toxicity; outcomes; radiation therapy; image guidance; pencil beam

(This special issue belongs to the Section Cancer Therapy)

Recent Trends in PET/CT Tracer Development and Multimodal Imaging

edited by

Olaf Prante

and

Tobias Bäuerle

submission deadline 30 Jun 2024 | 6 articles | Viewed by 14265 | Submission Open

Keywords: tracer development; multimodel imaging; multifunctional imaging agents; small animal PET; CT; SPECT; MR; ultrasound; fluorescence; treatment response; translational research

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Brachytherapy in the Treatment of Tumors

edited by

Hideya Yamazaki

submission deadline 30 Jun 2024 | 6 articles | Viewed by 12661 | Submission Open

Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Targeted Therapy in Gastrointestinal Cancer

edited by

Wei Kang

and

Ka Fai To

submission deadline 30 Jun 2024 | 6 articles | Viewed by 12389 | Submission Open

Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development

(This special issue belongs to the Section Cancer Therapy)

Advances in the Diagnosis and the Management of Intracranial Tumors

edited by

Moncef Berhouma

submission deadline 30 Jun 2024 | 11 articles | Viewed by 12104 | Submission Open

Keywords: intracranial tumors; gliomas; meningiomas; craniopharyngiomas; pituitary adenomas; CNS lymphomas; minimally invasive neurosurgery; multimodal brain imaging; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Therapy)

New Insights in Molecular Pathology of Cancers: From Biomarkers to Therapeutic Targets

edited by

Hisham Bahmad

submission deadline 30 Jun 2024 | 5 articles | Viewed by 11592 | Submission Open

Keywords: genomics; biomarkers; therapeutic target; personalized medicine; targeted therapy; genetic aberrations; molecular signatures; next-generation sequencing; diagnosis; prognosis

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances in Oncology Imaging

edited by

Li Liu

and

Yicheng Ni

submission deadline 30 Jun 2024 | 6 articles | Viewed by 9661 | Submission Open

Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Treatment of Bone Metastases

edited by

Michael Mørk Petersen

submission deadline 30 Jun 2024 | 6 articles | Viewed by 9496 | Submission Open

Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique

(This special issue belongs to the Section Cancer Therapy)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship

edited by

Thomas Licht

and

Richard Crevenna

submission deadline 30 Jun 2024 | 8 articles | Viewed by 8847 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Molecular Insights into Drug Resistance in Cancer

edited by Yang Yuqi

submission deadline 30 Jun 2024 | 7 articles | Viewed by 8009 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Cell Signaling in Cancer and Cancer Therapy

edited by

Zhixiang Wang

and

Yi Wang

submission deadline 30 Jun 2024 | 4 articles | Viewed by 7848 | Submission Open

Keywords: cell signaling; signal transduction; cancer therapy; radiation therapy; immune therapy; targeted therapy; chemotherapy; cell proliferation; cell death; cell motility

(This special issue belongs to the Section Molecular Cancer Biology)

Prognostic Factors in Urologic Cancers—Assessment and Integration into Clinical Care

edited by Maximilian Burger and Christian Thomas

submission deadline 30 Jun 2024 | 5 articles | Viewed by 7259 | Submission Open

Keywords: prognosis; prognostic factor; clinical management; prostate cancer; bladder cancer; renal cell cancer; uro-oncology; surgery; medical therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Cancer and Chronic Illness

edited by

Silvia Riondino

and

Vincenzo Formica

submission deadline 30 Jun 2024 | 5 articles | Viewed by 7225 | Submission Open

Keywords: cancer; chronic disease; inflammatory disease; cytokines; immune disease; radiotherapy-induced diseases; immunotherapy-induced disease; gastrointestinal chronic disorders; end-stage renal disease; lung cancer chronic disease

(This special issue belongs to the Section Cancer Pathophysiology)

Biomarkers for the Early Detection and Treatment of Cancers

edited by Barbara Mroczko and

Monika Gudowska-Sawczuk

submission deadline 30 Jun 2024 | 6 articles | Viewed by 6862 | Submission Open

Keywords: cancer; tumor biomarkers; tumor progression; early cancers; inflammatory mediators; early diagnosis

(This special issue belongs to the Section Cancer Biomarkers)

Targeting the Sphingolipid Metabolic Pathway: Promotion from Benchwarmer to the Starting Lineup—a Themed Issue in Memory of Dr’s. Lina Obeid and Mark Kester

edited by

Jeremy A. Hengst

submission deadline 30 Jun 2024 | 4 articles | Viewed by 6762 | Submission Open

Keywords: sphingolipid metabolic pathways; targeted therapeutics; cancer; drug resistance; rational drug combinations

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Diagnosis, Treatment and Management of Endocrine Neoplasms

edited by

Pietro Giorgio Calò

Salvatore Sorrenti

and

Fabio Medas

submission deadline 30 Jun 2024 | 5 articles | Viewed by 6335 | Submission Open

Keywords: thyroid carcinoma; thyroidectomy; parathyroid carcinoma; parathyroidectomy; adrenal gland neoplasms; adrenalectomy; neuroendocrine neoplasms

(This special issue belongs to the Section Cancer Therapy)

Cell Biology of Cancer Invasion

edited by

Hideki Yamaguchi

submission deadline 30 Jun 2024 | 5 articles | Viewed by 6044 | Submission Open

Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage

(This special issue belongs to the Section Molecular Cancer Biology)

Immune Checkpoint Inhibitors for Urologic Cancers

edited by

Panagiotis Vlachostergios

submission deadline 30 Jun 2024 | 5 articles | Viewed by 5838 | Submission Open

Keywords: identification of biomarkers for prostate; kidney and bladder cancer; neuroendocrine prostate cancer; PSMA theranostics; upper tract urothelial carcinoma; treatment-resistant urothelial carcinoma; genomics and immunogenomics for urological cancers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Bone and Spine Metastases

edited by

Kenichiro Kakutani

and

Yutaro Kanda

submission deadline 30 Jun 2024 | 5 articles | Viewed by 5760 | Submission Open

Keywords: bone metastases; spinal metastases; stereotactic body radiotherapy; conventional radiotherapy; spine surgery; spondylectomy; minimally invasive surgery; particle-beam radiotherapy; systemic agents; microenvironment

(This special issue belongs to the Section Cancer Metastasis)

Oncology: State-of-the-Art Research in France

edited by

Thierry Magnaldo

submission deadline 30 Jun 2024 | 4 articles | Viewed by 5188 | Submission Open

Intraductal Cancer of the Prostate (IDC-P): Diagnosis and Characterization

edited by

Eva M. Comperat

submission deadline 30 Jun 2024 | 5 articles | Viewed by 4811 | Submission Open

Keywords: atypical aspects of IDC-P; prognosis; diagnosis; recommendations; treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cancer Cell Metabolism and Drug Targets

edited by

Daniel S. Sitar

and Donald Miller

submission deadline 30 Jun 2024 | 3 articles | Viewed by 4251 | Submission Open

Keywords: metabolomics; cancer staging; tumor sensitization; biomarkers; tumor cell metabolism

(This special issue belongs to the Section Cancer Drug Development)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options

edited by

Giuseppe Palermo

submission deadline 30 Jun 2024 | 3 articles | Viewed by 4155 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Challenges and New Strategies in the Management of Pediatric Brain Tumors

edited by

Semi B. Harrabi

and

Adilia Hormigo

submission deadline 30 Jun 2024 | 2 articles | Viewed by 3965 | Submission Open

Keywords: low-grade glioma; high-grade glioma; ependymoma; medulloblastoma; craniopharyngioma; germinoma; molecular pathways; radiotherapy; targeted therapy; immunotherapy; neuroradiology; neurosurgery; new treatment strategies; long-term outcome

(This special issue belongs to the Section Pediatric Oncology)

Current Progress and Research Trends in Ocular Oncology

edited by Utta Berchner-Pfannschmidt,

Miltiadis Fiorentzis

and Nikolaos E. Bechrakis

submission deadline 30 Jun 2024 | 4 articles | Viewed by 3728 | Submission Open

Keywords: ocular oncology; uveal melanoma; conjunctival melanoma; retinoblastoma; primary tumor; recurrence; metastasis; oncogenic pathways; genetic and cellular heterogeneity; cancer immunity; diagnostic strategies; therapeutic options

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancer: Evolving Landscape and Emerging Therapies

edited by Takeshi Sano and

Stefan Mönig

submission deadline 30 Jun 2024 | 3 articles | Viewed by 3430 | Submission Open

Keywords: gastric cancer; epidemiology; pathology; endoscopy; surgery; systemic therapy

(This special issue belongs to the Section Cancer Therapy)

Diagnosis and Treatment for Hepatocellular Tumors (Volume II)

edited by

Georgios Germanidis

and Dimitris C. Zacharoulis

submission deadline 30 Jun 2024 | 3 articles | Viewed by 3360 | Submission Open

Keywords: HCC; diagnosis; BCLC-B; BCLC-C; anti-PD-1/PD-L1 immunotherapy; TKIs; combinations; TME; addiction loops; interventions; established data; neoadjuvant treatment; adjuvant treatment; definitive surgical treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in In Vivo Quantitative and Qualitative Imaging Characterization of Gliomas

edited by

Pierpaolo Alongi

and

Ignazio Gaspare Vetrano

submission deadline 30 Jun 2024 | 2 articles | Viewed by 3235 | Submission Open

Keywords: PET; PET/CT; PET/MR; MR; CT; OCT; US; gliomas; artificial intelligence; radiomics; in-vivo quantitative imaging

(This special issue belongs to the Section Methods and Technologies Development)

Innovative Prognostic Factors and Follow-Up of Localized Thoracic Malignancies

edited by

Ludovic Fournel

submission deadline 30 Jun 2024 | 2 articles | Viewed by 3147 | Submission Open

Keywords: prognosis; lung cancer; thoracic oncology; mesothelioma; neuroendocrine tumors; thymoma; sarcoma; surgery; multimodal treatment; rare tumors

(This special issue belongs to the Section Cancer Therapy)

Renal Cell Carcinoma: From Pathology to Therapeutic Strategies

edited by Jesús García-Donas

submission deadline 30 Jun 2024 | 3 articles | Viewed by 2932 | Submission Open

Keywords: kidney cancer; translational research; genomics; transcriptomics; clear cell; non-clear cell

(This special issue belongs to the Section Molecular Cancer Biology)

Setting the Standards for Malignancies of the Nose Vestibule

edited by

Francesco Bussu

Luca Tagliaferri

and

Piero Nicolai

submission deadline 30 Jun 2024 | 2 articles | Viewed by 2897 | Submission Open

Keywords: nose malignancies; TNM staging of the nose and paranasal sinuses; interventional radiotherapy; brachytherapy; external beam radiotherapy; skin malignancies; nose reconstruction; nose function; nose prosthesis; epithesis

(This special issue belongs to the Section Cancer Therapy)

Advances in Skin Cancer Diagnostics and Therapy: Research and Clinical Studies

edited by Cristel Ruini

submission deadline 30 Jun 2024 | 4 articles | Viewed by 2787 | Submission Open

Keywords: non-melanoma skin cancer; melanoma; actinic keratosis; field cancerisation; medical diagnostics; dermatology; dermoscopy; optical coherence tomography; in vivo confocal microscopy; ex vivo confocal microscopy; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Advanced Diagnostics and Optical Imaging Technologies in Cancer Research

edited by Vlad Mihai Voiculescu

submission deadline 30 Jun 2024 | 3 articles | Viewed by 2724 | Submission Open

Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies

(This special issue belongs to the Section Methods and Technologies Development)

The Biology of CD44 and Its Role in Cancer Progression: Therapeutic Implications

edited by

Paraskevi Heldin

submission deadline 30 Jun 2024 | 2 articles | Viewed by 2638 | Submission Open

Keywords: CD44; hyaluronan; receptor tyrosine kinase; cytokine receptors; tumour microenvironment; stemness; metastases; prognostic factor; vascular leakage; tumour-derived exosomes

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Research Advances in Chronic Lymphocytic Leukemia (CLL)

edited by

Spencer Gibson

submission deadline 30 Jun 2024 | 2 articles | Viewed by 2130 | Submission Open

Keywords: treatments; drug resistance; toxicities; immune system; microenvironment; patient management

(This special issue belongs to the Section Clinical Research of Cancer)

Immune Checkpoint Inhibitor-Based Immunotherapy in Cancer: Predictive Biomarkers and Mechanisms of Resistance

edited by

Paul Takam Kamga

submission deadline 30 Jun 2024 | 2 articles | Viewed by 2118 | Submission Open

Keywords: cancer; immunotherapy; ICIs; immuno-resistance; predictive biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Novel Targeted Therapy, Immunotherapy, and Immune Biomarkers for Gastroesophageal and Liver Cancer

edited by Anwaar Saeed and

Ludimila Cavalcante

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1777 | Submission Open

Keywords: immunotherapy; targeted therapy; immune checkpoint inhibitors; gastroesophageal cancer; liver cancer; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors (Volume II)

edited by

Anna Pasetto

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1707 | Submission Open

Keywords: TCR ; CAR ; solid tumors ; mutated antigens ; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

Plasma Proteomics Analysis Predicts Cancer Biomarkers

edited by

Seong Beom Ahn

and

Abidali Mohamedali

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1621 | Submission Open

Keywords: plasma proteomics; mass spectrometry-based technologies; antibody-based technologies; cancer biomarkers; cancer biology; diagnostic makers; prognostic makers; predictive analysis; early detection; bioinformatics

(This special issue belongs to the Section Methods and Technologies Development)

Pathology and Treatment of Triple-Negative Breast Cancer

edited by

Ramadevi Subramani

submission deadline 30 Jun 2024 | 2 articles | Viewed by 1554 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances on Innovative Radiopharmaceuticals in Preclinical and Clinical Cancer Research

edited by Désirée Déandréis and

Roberto Passera

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1534 | Submission Open

Keywords: nuclear medicine; radiopharmaceutical; PET-CT; clinical trial; preclinical trial; cancer; clinical oncology; solid tumors; oncohematology; PRRT; urologic oncology

(This special issue belongs to the Section Cancer Drug Development)

Regulators of Breast Cancer Metastasis

edited by

Terumi Kohwi-Shigematsu

and Saori Furuta

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1462 | Submission Open

Keywords: tumor progression regulators; metastasis; tumor microenvironment; biomarkers for recurrence; transcriptional regulation; chromatin structure; epigenetics; cancer metabolism; cancer immunity; microbiome

(This special issue belongs to the Section Cancer Metastasis)

Clinicopathological Study of Gynecologic Cancer

edited by

Origoni Massimo

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1316 | Submission Open

Keywords: gynecological oncology; gynaecological cancer; female cancer; uterine cancer; ovarian cancer; endometrial cancer; cancerogenesis; cancer biology; cell transformation; cancer pathology; cancer biology

(This special issue belongs to the Section Clinical Research of Cancer)

New Approaches in Leukemia

edited by

Harinder Gill

, Naveen Pemmaraju, Hsin-An Hou and Melissa Gaik Ming Ooi

submission deadline 30 Jun 2024 | 1 articles | Viewed by 1179 | Submission Open

Keywords: acute myeloid leukemia; acute promyelocytic leukemia; acute lymphoblastic leukemia; blastic plasmacytoid dendritic cell neoplasm (BPDCN); myelodysplastic neoplasm (MDS); myeloproliferative neoplasm (MPN); chronic myeloid leukemia (CML); chronic lymphocytic leukemia (CLL)

(This special issue belongs to the Section Cancer Biomarkers)

Genomic, Epigenomic, and Transcriptomic Landscapes of Brain Cancers

edited by

Shota Tanaka

and

Joseph Papamatheakis

submission deadline 30 Jun 2024 | 1 articles | Viewed by 960 | Submission Open

Keywords: genomic; epigenomic; transcriptomic; glioma; brain tumor; glioblastoma; medulloblastoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma

edited by Josep Maria Caminal Mitjana

submission deadline 30 Jun 2024 | 1 articles | Viewed by 566 | Submission Open

Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

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