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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Treatment of Bone Metastases: 2nd Edition

edited by

Michael Mørk Petersen

submission deadline 29 Aug 2025 | 2 articles | Viewed by 4519 | Submission Open

Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 29 Aug 2025 | 1 articles | Viewed by 1130 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

CRISPR in Cancer Biology and Therapy: 2nd Edition

edited by

Shun-Qing Liang

submission deadline 29 Aug 2025 | Viewed by 300 | Submission Open

Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Drug Repurposing to Overcome Cancers

edited by

Rafal Bartoszewski

submission deadline 30 Aug 2025 | 6 articles | Viewed by 13119 | Submission Open

Keywords: drug development; drug repurposing; drug resistance; pharmacological; cancers therapy

(This special issue belongs to the Section Cancer Drug Development)

Advances in Tumor Vascular Imaging

edited by

Eiichi Ishikawa

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2414 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Pathology of Acute Myeloid Leukemia (AML)

edited by Olga K. Weinberg

submission deadline 30 Aug 2025 | Viewed by 1178 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Aug 2025 | Viewed by 235 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment of Oral Squamous Cell Carcinoma

edited by Kai-Ping Chang and Huang-Kai Kao

submission deadline 30 Aug 2025 | Viewed by 231 | Submission Open

Keywords: oral cavity; squamous cell carcinoma; OSCC; surgery; head and neck; resection; reconstruction; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Oncology: State-of-the-Art Research in Germany

edited by

Orlando Guntinas-Lichius

submission deadline 31 Aug 2025 | 26 articles | Viewed by 54715 | Submission Open

Keywords: cancer; oncology; research; Germany; cancer care

New Concepts and Recent Advances in the Management of Skin Cancer

edited by

Rafael Salido-Vallejo

and

Pedro Redondo

submission deadline 31 Aug 2025 | 13 articles | Viewed by 33178 | Submission Open

Keywords: skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; melanoma; Merkel cell carcinoma; cutaneous sarcomas; treatment; checkpoint inhibitors; epidemiology; dermatologic surgery; extramammary paget's disease; cutaneous lymphoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Thoracic Oncology: A Multi-disciplinary Approach to Lung Cancer

edited by Percy Lee, Jyoti Malhotra and

Arya Amini

submission deadline 31 Aug 2025 | 12 articles | Viewed by 27201 | Submission Open

Keywords: small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Cutaneous Lymphoma

edited by Michi M. Shinohara

submission deadline 31 Aug 2025 | 6 articles | Viewed by 21748 | Submission Open

Keywords: primary cutaneous lymphoma; cutaneous T-cell lymphoma; mycosis fungoides; Sé zary syndrome; health-related quality of life

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal Malignancy: Epidemiology and Risk Factors

edited by Patrick Okolo and Chengu Niu

submission deadline 31 Aug 2025 | 5 articles | Viewed by 21118 | Submission Open

Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Therapies and Immunological Findings in Nasopharyngeal Carcinoma

edited by Dora Kwong and Darren Wan Teck Lim

submission deadline 31 Aug 2025 | 4 articles | Viewed by 10961 | Submission Open

Keywords: EBV; tumor microenvironment; neoantigens; checkpoint inhibitors; cellular immunotherapy; vaccine; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk

edited by

Ariane Zamoner

Marco G. Alves

and

Ana Paula S. Perez

submission deadline 31 Aug 2025 | 5 articles | Viewed by 8570 | Submission Open

Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone

(This special issue belongs to the Section Tumor Microenvironment)

Robotic Surgery for Gastrointestinal (GI) Malignancies

edited by

Yaron Rudnicki

and

Shmuel R. Avital

submission deadline 31 Aug 2025 | 5 articles | Viewed by 6779 | Submission Open

Keywords: robotic surgery; colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; esophageal cancer; robotic platform

(This special issue belongs to the Section Clinical Research of Cancer)

Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life

edited by Shingen Nakamura

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6511 | Submission Open

Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 31 Aug 2025 | 3 articles | Viewed by 6391 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

2nd Edition: Molecular Testing for Thyroid Nodules and Cancer

edited by

Marc P. Pusztaszeri

and

Richard J. Payne

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6184 | Submission Open

Keywords: thyroid nodules; thyroid cancer; molecular testing; cytology; fine needle aspiration; personalized medicine; mutations

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Therapies in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by

Amir A. Rahnemai Azar

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5734 | Submission Open

Keywords: hepatocellular carcinoma; colorectal cancer; esophageal cancer; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations

edited by Jun Zhou

submission deadline 31 Aug 2025 | 2 articles | Viewed by 5100 | Submission Open

Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Diagnosis and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (2nd Edition)

edited by Peter Stålberg

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4961 | Submission Open

Keywords: biomarkers; imaging; gastric NETs; pancreatic NETs; small intestinal NETs; receptor-based therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Advances on the Role of Intensity–Modulated Radiotherapy in Cancer

edited by Taro Murai

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4886 | Submission Open

Keywords: intensity modulated radiotherapy; medical physics; stereotactic radiotherapy; proton therapy; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Liquid Biopsy in Breast Cancer (2nd Edition)

edited by

Maria Papadaki

and

Dimitrios Mavroudis

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4715 | Submission Open

Keywords: liquid biopsy; liquid biomarkers; precision oncology; disease monitoring; treatment monitoring; tumor heterogenei-ty; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); circulating miRNAs; exosomes; extracellular vesicles (EVs)

(This special issue belongs to the Section Cancer Biomarkers)

Paradigm Shifts in Gynaecological Oncology Surgery

edited by

Faiza Gaba

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4601 | Submission Open

Keywords: gynecological surgery; genomics risk management; survivorship health economics

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Management of Prostate Cancer: New Insights into Biological and Clinical Factors

edited by Mutlay Sayan and

Yetkin Tuac

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4554 | Submission Open

Keywords: prostate cancer; risk stratification; genomic alterations; radiation therapy; prostatectomy; androgen deprivation therapy

(This special issue belongs to the Section Cancer Therapy)

Combination Therapy in Lymphoma

edited by

Afua Adjeiwaa Mensah

and Alberto Arribas

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4452 | Submission Open

Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents

(This special issue belongs to the Section Cancer Therapy)

Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches

edited by

Md Ataur Rahman

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4216 | Submission Open

Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Cancer Metastasis)

Lectins in Cancer

edited by

Maciej Cedzyński

and Anna S. Świerzko

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4062 | Submission Open

Keywords: lectin; sugar code; epithelial to mesenchymal transition (EMT); metastasis; complement; oncogenic pathogen

(This special issue belongs to the Section Cancer Metastasis)

Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries

edited by Russell Rockne,

and

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4046 | Submission Open

Keywords: mathematical oncology; computational biology; mathematical modeling; computational oncology; data-driven modeling; physical oncology

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in Melanoma: Recent Advances and Future Directions (2nd Edition)

edited by

Dimitrios C. Ziogas

and

Helen Gogas

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3923 | Submission Open

Keywords: melanoma; immunotherapy; prognostic and predictive biomarkers; recurrence-free and overall survival; adjuvant/neoadjuvant immunotherapy; anti-PD1/anti-PD-L1 and anti-CTLA4 agents

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Novel Insights into Cancer-Related Cognitive Impairment

edited by Danielle Tometich

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3512 | Submission Open

Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies

edited by Akshay Jatin Patel and Marcus Taylor

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2892 | Submission Open

Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy

(This special issue belongs to the Section Methods and Technologies Development)

Applications of Ex Vivo Microscopy in Cancer Detection and Diagnosis

edited by J. Quincy Brown

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2617 | Submission Open

Keywords: microscopy; cancer; optical sectioning; diagnosis; detection

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Current Treatments of Esophageal and Esophagogastric Junction Cancers

edited by

Masanobu Nakajima

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2610 | Submission Open

Keywords: esophageal cancer; esophagogastric junction cancer; endoscopic resection; surgery; minimally invasive surgery; robotic surgery; chemotherapy; chemoradiotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

New Insights into Robotic Surgery for Urologic Cancer

edited by Neil Mendhiratta and

Michael Whalen

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2599 | Submission Open

Keywords: urologic oncology; genitourinary cancers; robotics; robotic surgery techniques; robotics simulation training; resident education; artificial intelligence for surgical training; surgical coaching; economics of robotic surgery; surgery financial toxicity

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Research in Gastrointestinal Cancers (2nd Edition)

edited by

Savio Barreto

and

Jörg Kleeff

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2536 | Submission Open

Keywords: surgery; chemotherapy; radiation therapy; outcomes; quality of life; survival; survivorship; biomarkers; imaging

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immunomodulation in Cancer Treatment

edited by Samuel D. Saibil

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1946 | Submission Open

Keywords: adoptive cell therapy; TILs; TCT-T; BiTes; CAR-T; immuno-metabolism; immune therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

From Genomics and Immunogenomics to Treatments of Head and Neck Cancer (2nd Edition)

edited by Yan Cui and Vivian Wai Yan Lui

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1815 | Submission Open

Keywords: head and neck cancer; genomics; immunogenomics; multi-omics; immunotherapy; translational research; preclinical drug development; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

Meningioma Recurrences: Risk Factors and Management

edited by

Francesco Maiuri

and Marialaura Del Basso De Caro

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1624 | Submission Open

Keywords: meningioma; recurrences; risk factors

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Mechanisms of Cancer-Associated Thrombosis

edited by Tom A J Mckinnon

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: cancer; thrombosis; venous; arterial

(This special issue belongs to the Section Clinical Research of Cancer)

Genomic Analysis of Breast Cancer

edited by

Hiroshi Tada

and

Hiroko Masuda

submission deadline 31 Aug 2025 | 1 articles | Viewed by 790 | Submission Open

Keywords: breast cancer; comprehensive genomic profiling; molecular-matched therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Circulating Tumor Cells: Origin, Fate, and Roles in Immune Evasion and Metastasis

edited by

Luis Del Pozo-Yauner

and

Ajay Pratap Singh

submission deadline 31 Aug 2025 | Viewed by 788 | Submission Open

Keywords: circulating tumor cells; cancer immunotherapy; PD-1/PD-L1; unfolded protein response; cell stress; carcinogenesis; polyploid giant cancer cells; biomarkers; early diagnosis; prognosis; monitoring of therapeutic response

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Autophagy in Brain Tumors (Volume II)

edited by

Gabriella D’Orazi

submission deadline 31 Aug 2025 | Viewed by 558 | Submission Open

Keywords: glioblastomas; cancer treatment; chemoresistance; autophagy; autophagy inhibitors; autophagy activators; novel therapeutics; targeted therapy; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer

edited by Wenqing Cao

submission deadline 31 Aug 2025 | Viewed by 527 | Submission Open

Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer Progression: From Experimental Models to Clinical Applications: 2nd Edition

edited by

Marcin Iwanicki

and

Mikołaj Piotr Zaborowski

submission deadline 31 Aug 2025 | Viewed by 425 | Submission Open

Keywords: ovarian cancer progression; ovarian cancer spheroids; ovarian cancer organoids; ovarian cancer patient-derived xenograft models; genetically modified mouse models of ovarian cancer; mesothelial cells; mesenchymal stem cells; cancer-associated fibroblasts; ovarian cancer innervation; immune models of ovarian cancer; omics of ovarian cancer; clinical imaging of ovarian cancer; metastasis; relapse; modelling

(This special issue belongs to the Section Methods and Technologies Development)

Photodynamic Therapy for Cancers: An Update

edited by

Jiro Akimoto

submission deadline 31 Aug 2025 | Viewed by 372 | Submission Open

Keywords: photodynamic therapy; photosensitizer; cancer therapy; laser; reactive oxygen species; apoptosis; optical fiber

(This special issue belongs to the Section Cancer Therapy)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 Aug 2025 | Viewed by 300 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

CAR T-Cell Therapy and Multiple Myeloma

edited by Jo Caers

submission deadline 31 Aug 2025 | Viewed by 276 | Submission Open

Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Progress in Modelling, Understanding of Cellular Biology of Prostate Cancer

edited by Benyi Li

submission deadline 31 Aug 2025 | Viewed by 238 | Submission Open

Keywords: prostate cancer; cellular biology; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

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