Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Metastatic Prostate Cancer
edited by
submission deadline 21 Apr 2025 | 2 articles | Viewed by 3033
Keywords: prostate cancer; genomic profiling; therapeutic sequences; immunotherapy; chemotherapy; hormone-therapy; molecular imaging
(This special issue belongs to the Section Cancer Metastasis)
Research on Early Diagnosis and Treatment of Gastric Cancer
edited by Katsunori Iijima
submission deadline 25 Apr 2025 | 2 articles | Viewed by 3149 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology
edited by
submission deadline 25 Apr 2025 | 1 articles | Viewed by 3078 | Submission Open
Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Nanotechnology in Ovarian Cancer: Diagnosis and Treatment
edited by Shailendra Kumar Dhar Dwivedi
submission deadline 25 Apr 2025 | Viewed by 744 | Submission Open
Keywords: ovarian cancer; nanotechnology; tumor microenvironment; gynecological malignancies
(This special issue belongs to the Section Methods and Technologies Development)
Targeting Hallmarks of Cancer submission deadline 25 Apr 2025 | Viewed by 498 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
(This special issue belongs to the Section Cancer Biomarkers)
Updates on Depression among Cancer Patients
edited by Wen-Yu Hu, and
submission deadline 28 Apr 2025 | 5 articles | Viewed by 8327 | Submission Open
Keywords: depression; cancer patients; mental health; psycho-oncology; treatment; psychosocial interventions; survivorship; comorbidity; quality of life; neurobiology
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Metabolic Landscape of Gynecological Cancer: Identifying Targets for Therapeutic Intervention
edited by
submission deadline 28 Apr 2025 | 1 articles | Viewed by 3264 | Submission Open
(This special issue belongs to the Section Molecular Cancer Biology)
How to Properly Diagnose and Treat Immune-Related Adverse Events during Immunotherapy in Patients with Cancer: Discussion between Specialists submission deadline 30 Apr 2025 | 14 articles | Viewed by 35969 | Submission Open
Keywords: ICIs; immune-related adverse effects (irAEs); infectious complications; immune reconstitution; inflammatory syndrome (IRIS); microbiota; vaccines; molecular mimicry
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeting the Tumor Microenvironment (Volume II) submission deadline 30 Apr 2025 | 11 articles | Viewed by 22025 | Submission Open
Keywords: microenvironment; cancer treatment; resistance to treatment; metastasis; immune response; immune cells; fibroblasts; angiogenesis; EVs; signalling
(This special issue belongs to the Section Tumor Microenvironment)
Molecular Pathology of Brain Tumors
edited by Ho-Keung NG
submission deadline 30 Apr 2025 | 9 articles | Viewed by 17303 | Submission Open
Keywords: molecular pathology; brain tumors; AI; biomarkers; histopathology
(This special issue belongs to the Section Molecular Cancer Biology)
Quality of Life and Side Effects Management in Cancer Treatment (Volume II)
edited by
submission deadline 30 Apr 2025 | 9 articles | Viewed by 13715 | Submission Open
Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Adaptive Resistance to Targeted Cancer Therapies and Rational Development of Combination Therapies submission deadline 30 Apr 2025 | 8 articles | Viewed by 13425 | Submission Open
Keywords: targeted therapies; cancer drug resistance; adaptive resistance; signal transduction networks; network adaptation; cell state transitions
(This special issue belongs to the Section Cancer Therapy)
Evidence from the Real World Provides New Insights into the Evolving Landscape of Cancer Immunotherapy
edited by Fabrizio Nelli, and Enzo Ruggeri
submission deadline 30 Apr 2025 | 6 articles | Viewed by 12918 | Submission Open
Keywords: immune-checkpoint inhibitors; solid tumors; cytotoxic chemotherapy; targeted therapies; radiotherapy; concomitants medications; supportive therapies; real-world investigation
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Acute Myeloid Leukemia in Adults submission deadline 30 Apr 2025 | 4 articles | Viewed by 8166 | Submission Open
Keywords: acute myeloid leukemia; molecular biology; treatment landscape; resistance mechanisms
(This special issue belongs to the Section Clinical Research of Cancer)
Potential Therapeutic Targets and Non-invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies submission deadline 30 Apr 2025 | 3 articles | Viewed by 8119 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer
edited by Kelsie L. Thu
submission deadline 30 Apr 2025 | 5 articles | Viewed by 7070 | Submission Open
Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Brain Metastases: From Mechanisms to Treatment
edited by Dawen Zhao and Michael Chan
submission deadline 30 Apr 2025 | 5 articles | Viewed by 6623 | Submission Open
Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy
(This special issue belongs to the Section Cancer Metastasis)
Long-Read Sequencing in Cancer
edited by and Patrick Driguez
submission deadline 30 Apr 2025 | 1 articles | Viewed by 6355 | Submission Open
Keywords: long-read sequencing; cancer genetics; genomics; transcriptomics; methylomics; cancer research
(This special issue belongs to the Section Cancer Informatics and Big Data)
Advances in Uveal Melanoma
edited by and
submission deadline 30 Apr 2025 | 4 articles | Viewed by 5819 | Submission Open
Keywords: uveal melanoma; eye cancer; liver metastasis; Gα q/11 mutations; BAP1; SF3B1; PRAME; dormancy; liver-directed treatment; T-cell engager
(This special issue belongs to the Section Molecular Cancer Biology)
Emerging Insights into Cell Death in Cancer
edited by
submission deadline 30 Apr 2025 | 3 articles | Viewed by 5549 | Submission Open
Keywords: cell death; cancer; apoptosis; programmed cell death (PCD); regulated cell death (RCD); therapeutic strategies; molecular mechanisms; drug discovery; cellular pathways; biomarkers; immunotherapy; targeted therapy; cellular signaling; apoptotic regulators
(This special issue belongs to the Section Molecular Cancer Biology)
Radiomics in Head and Neck Cancer Care
edited by
submission deadline 30 Apr 2025 | 3 articles | Viewed by 5357 | Submission Open
Keywords: radiomics; personalized therapeutic approach; radiology; improving outcome; head and neck cancer; imaging biomarkers; artificial intelligence
(This special issue belongs to the Section Methods and Technologies Development)
Skin Cancer and Environmental Exposure submission deadline 30 Apr 2025 | 4 articles | Viewed by 5148 | Submission Open
Keywords: skin cancer; melanoma; non-melanoma skin cancer; environmental factors; ultraviolet (UV) radiation; DNA damage; etiology; prevention and treatment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Curative Therapies for Non-Small Cell Lung Cancer
edited by John Michael Varlotto
submission deadline 30 Apr 2025 | 3 articles | Viewed by 5007 | Submission Open
Keywords: radiotherapy; surgery; early-stage NSCLC; oligometastases; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Advancements in Molecular Research of Prostate Cancer
edited by
submission deadline 30 Apr 2025 | 4 articles | Viewed by 4533 | Submission Open
Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Spatial, Bulk, and Cell-Type-Related Transcriptomics in Cancer Research
edited by Xinmin Li, and
submission deadline 30 Apr 2025 | 1 articles | Viewed by 4326 | Submission Open
Keywords: translational transcriptomics; cancer research; spatial transcriptomics; drug sensitivity and responsiveness; immune checkpoint inhibitors; targeted drugs; chemotherapy; radiation therapy; cell-based therapy; anticancer vaccines
(This special issue belongs to the Section Methods and Technologies Development)
Venetoclax in Acute Myeloid Leukemia
edited by Mika Kontro, Heikki Kuusanmäki and Martin Jädersten
submission deadline 30 Apr 2025 | 1 articles | Viewed by 3859 | Submission Open
Keywords: acute myeloid leukemia (AML); venetoclax; BCL-2 inhibitor; response prediction; combination therapy; targeted therapies
(This special issue belongs to the Section Cancer Therapy)
Neoadjuvant Chemotherapy for Breast Cancer
edited by Shin-Cheh Chen
submission deadline 30 Apr 2025 | 1 articles | Viewed by 3502 | Submission Open
Keywords: breast cancer; neoadjuvant chemotherapy; molecular subtype; response predictor; survival surrogate; immune checkpoint inhibitor; pathological complete response
(This special issue belongs to the Section Cancer Therapy)
Role of Extracellular Vesicles in Cancer Progression submission deadline 30 Apr 2025 | 2 articles | Viewed by 3485 | Submission Open
Keywords: extracellular vesicles; cancer progression; tumor microenvironment; tumor– immune landscape cross-talk pre-metastatic and metastatic niches; immune surveillance; EV-based biomarkers; EV-based therapeutic development
(This special issue belongs to the Section Tumor Microenvironment)
Role of Cytokines in Cancer submission deadline 30 Apr 2025 | 3 articles | Viewed by 3439 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Features and Molecular Pathology of Melanomas submission deadline 30 Apr 2025 | 2 articles | Viewed by 2538 | Submission Open
Keywords: melanoma; biological behavior; prognosis; clinical and histological prognostic factors
(This special issue belongs to the Section Molecular Cancer Biology)
Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models submission deadline 30 Apr 2025 | 2 articles | Viewed by 2392 | Submission Open
Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Application of Nanoparticles in Cancer Research
edited by Sreejith Raveendran
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1544 | Submission Open
Keywords: targeted therapeutics; combination therapeutics; cell and gene therapies; nanodrug delivery; cancer drug discovery; biosensors; molecular therapeutics; molecular imaging; smart nanoparticles; biomimetic nanoparticles
(This special issue belongs to the Section Methods and Technologies Development)
The Experimental Biology of Carcinogenesis: From Basic Research to Clinical Applications submission deadline 30 Apr 2025 | Viewed by 654 | Submission Open
Keywords: human anatomy; histology; microscopy; cell differentiation; tissue homeostasis; organ remodeling; chaperoning system; extracellular vesicles; molecular mimicry; vaccines; carcinogenesis
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in Section “Cancer Survivorship and Quality of Life” in 2024–2025 submission deadline 30 Apr 2025 | Viewed by 421 | Submission Open
Keywords: patient care; nurse education; management policy development; nursing cancer; care survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Emerging Role of Multiplexed Imaging for Cancer Diagnosis and Therapy
edited by and Yicheng Ni
submission deadline 30 Apr 2025 | Viewed by 331 | Submission Open
Keywords: multiplexed imaging; cancer diagnosis; molecular imaging; novel contrast agents; targeted radionuclide tracers; theragnostics; personalized cancer therapy; therapeutic monitoring; imaging biomarkers; clinical translation
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Lung Cancer: Updates on Therapy and Efficacy/Toxicity Prediction submission deadline 30 Apr 2025 | Viewed by 282 | Submission Open
Keywords: lung cancer; targeted therapy; immunotherapy; chemotherapy; radiotherapy; surgery; toxicity; biomarkers; prediction
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer Imaging: Current Trends and Future Direction (2nd Edition)
edited by
submission deadline 30 Apr 2025 | Viewed by 277 | Submission Open
Keywords: breast cancer; mammography; ultrasound; magnetic resonance imaging— MRI; molecular breast imaging; PET/CT; PET/MRI; artificial intelligence; machine learning; radiomics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances on Imaging and Treatment of Head and Neck Cancer
edited by Yading Yuan, Vishruta A. Dumane, and Luqman Dad
submission deadline 30 Apr 2025 | Viewed by 277 | Submission Open
Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning
(This special issue belongs to the Section Cancer Therapy)
Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy
edited by Antonio Pontoriero
submission deadline 30 Apr 2025 | Viewed by 251 | Submission Open
Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation
(This special issue belongs to the Section Cancer Therapy)
Precision Medicine in Lung Cancer
edited by Gang Wang and
submission deadline 30 Apr 2025 | Viewed by 232 | Submission Open
Keywords: lung cancer; biomarkers; targeted therapy; precision medicine; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Biomarkers of Ovarian Cancer Progression
edited by Yang Yang-Hartwich
submission deadline 30 Apr 2025 | Viewed by 201 | Submission Open
Keywords: ovarian cancer; biomarkers; prognosis; blood biomarkers; tissue biomarkers; tumor progression; treatment response
(This special issue belongs to the Section Cancer Biomarkers)
Resection Versus Transplant for Hepatocellular Carcinoma
edited by
submission deadline 30 Apr 2025 | Viewed by 197 | Submission Open
Keywords: liver resection; hepatocellular carcinoma; liver transplantation; vascular invasion; Milan criteria
(This special issue belongs to the Section Cancer Therapy)
Novel Diagnostic and Therapeutic Approaches in Diffuse Gliomas submission deadline 1 May 2025 | 5 articles | Viewed by 10747 | Submission Open
Keywords: diffuse gliomas; glioblastoma; neuro-oncology; neurosurgery; radiomics; liquid biopsies; immunotherapy; epigenetics; targeted therapy; imaging
(This special issue belongs to the Section Cancer Biomarkers)
Flow Cytometry of Hematological Malignancies
edited by and Franklin S. Fuda
submission deadline 1 May 2025 | 8 articles | Viewed by 10617 | Submission Open
Keywords: flow cytometry; minimal or measurable residual disease (MRD); immunotherapy; leukemia; lymphoma; myeloma; chimeric antigen receptor T cells (CAR-T); bispecific T-cell engager (BiTE); B-cell maturation antibody (BCMA); spectral flow cytometry; machine learning
(This special issue belongs to the Section Methods and Technologies Development)
Rare Tumors in Children: Trends in Diagnosis, Treatment and Prevention (2nd Edition) submission deadline 1 May 2025 | 3 articles | Viewed by 3110 | Submission Open
Keywords: pediatric oncology; pediatric drugs; clinical pharmacology
(This special issue belongs to the Section Pediatric Oncology)
Advances in Neuro-Oncological Imaging (Volume II) submission deadline 1 May 2025 | 2 articles | Viewed by 2408 | Submission Open
Keywords: central nervous system (CNS) tumors; brain tumors; spinal cord tumors; magnetic resonance imaging (MRI); positron emission tomography (PET); intraoperative MRI; imaging biomarkers; metabolic imaging; radiomics; machine learning
(This special issue belongs to the Section Methods and Technologies Development)
The Advances in Therapy for Hepatocellular Carcinoma submission deadline 1 May 2025 | Viewed by 499 | Submission Open
Keywords: lenvatinib; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemo infusion therapy; radiation therapy; radiofrequency ablation; systemic therapy; surgery; surgical resection; locoregional therapy
(This special issue belongs to the Section Cancer Therapy)
Lynch Syndrome (HNPCC): Symptoms, Causes, and Outlooks
edited by
submission deadline 1 May 2025 | Viewed by 451 | Submission Open
Keywords: Lynch syndrome; genotype– phenotype correlation; highly immunogenic frame-shift neo-peptides; immunotherapy; mismatch repair genes; unclassified genetic variants; new role of MMR proteins; miRNAs; functional assay MMR deficiency
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Immunotherapy: A New Frontier in Thyroid Cancer Treatment
edited by Jessica Lyn Geiger
submission deadline 1 May 2025 | Viewed by 189 | Submission Open
Keywords: thyroid cancer; immunotherapy; checkpoint inhibitors; PD-1/PD-L1 inhibitors; CTLA-4 inhibitors; targeted therapy; vaccines; adoptive cell therapy; clinical trials; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors (2nd Edition)
edited by
submission deadline 5 May 2025 | 2 articles | Viewed by 5789 | Submission Open
Keywords: TCR  ; CAR  ; solid tumors  ; mutated antigens  ; clinical trials
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
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