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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Brachytherapy in the Treatment of Tumors
edited by
submission deadline 30 Nov 2025 | 12 articles | Viewed by 36443
Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Novel Therapeutic Approaches for Cancer Treatment submission deadline 30 Nov 2025 | 13 articles | Viewed by 35152
Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Radiomics and Imaging in Cancer Analysis submission deadline 30 Nov 2025 | 13 articles | Viewed by 27288
Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology
(This special issue belongs to the Section Methods and Technologies Development)
Immunotherapy in the Management of Hematologic Malignancy
edited by Mohammad S. Hossain
submission deadline 30 Nov 2025 | 6 articles | Viewed by 22875
Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Skin Cancers
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 20232
Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system
(This special issue belongs to the Section Cancer Therapy)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Nov 2025 | 11 articles | Viewed by 15403
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Sarcoma: Clinical Trials and Management submission deadline 30 Nov 2025 | 6 articles | Viewed by 14389
Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma
(This special issue belongs to the Section Clinical Research of Cancer)
Advancements in Surgical Approaches for Gynecological Cancers submission deadline 30 Nov 2025 | 10 articles | Viewed by 13781
Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins
(This special issue belongs to the Section Cancer Therapy)
The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 12173
Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1
(This special issue belongs to the Section Tumor Microenvironment)
Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions
edited by Yongwoo Dave Seo
submission deadline 30 Nov 2025 | 4 articles | Viewed by 11956
Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design
(This special issue belongs to the Section Cancer Therapy)
Advances in Esophageal Cancer Treatment
edited by , , Pieter Van der Sluis and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 10742
Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Novel Advances in Surgery for Prostate Cancer
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 10109
Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Research on Fluorescence-Guided Surgery in Cancer Treatment
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 9948
Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy
(This special issue belongs to the Section Cancer Therapy)
Cell Therapy in Solid Cancers: Current and Future Landscape
edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin
submission deadline 30 Nov 2025 | 2 articles | Viewed by 9166
Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell
(This special issue belongs to the Section Cancer Therapy)
Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging
edited by Andra Valentina Krauze
submission deadline 30 Nov 2025 | 4 articles | Viewed by 8130
Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations
(This special issue belongs to the Section Methods and Technologies Development)
Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)
edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7926
Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches
(This special issue belongs to the Section Cancer Therapy)
Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 7420
Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome
(This special issue belongs to the Section Cancer Therapy)
Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis (2nd Edition)
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 4775
Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis
(This special issue belongs to the Section Molecular Cancer Biology)
Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer submission deadline 30 Nov 2025 | 1 articles | Viewed by 4475
Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach
(This special issue belongs to the Section Methods and Technologies Development)
Tissue-Agnostic Drug Development in Cancer (2nd Edition)
edited by Shivaani Kummar and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3934
Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine
(This special issue belongs to the Section Cancer Drug Development)
Molecular Pathways in Cancers (2nd Edition) submission deadline 30 Nov 2025 | 2 articles | Viewed by 3631
Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis
(This special issue belongs to the Section Molecular Cancer Biology)
Image Analysis and Machine Learning in Cancers: 2nd Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 3306
Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network
(This special issue belongs to the Section Methods and Technologies Development)
Calcium Signaling in Cancer Cell Progression
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2884
Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Tumor Microenvironment in Primary Liver Cancer 2nd edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 2802
Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers submission deadline 30 Nov 2025 | 2 articles | Viewed by 2057
Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Castration-Resistant Prostate Cancer Treatment submission deadline 30 Nov 2025 | 1 articles | Viewed by 1834
Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)
edited by Cesare Guida and Ida D'Onofrio
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1029
Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers
(This special issue belongs to the Section Cancer Therapy)
Clinical and Surgical Therapy for Colorectal Cancer
edited by Laura Koskenvuo
submission deadline 30 Nov 2025 | 1 articles | Viewed by 919
Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in the Molecular Genetics of Sarcomas
edited by Wei Jiang
submission deadline 30 Nov 2025 | Viewed by 501
Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification
(This special issue belongs to the Section Molecular Cancer Biology)
Mesothelioma: Diagnosis and Therapy
edited by Avinash Aujayeb
submission deadline 30 Nov 2025 | 1 articles | Viewed by 389
Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy
(This special issue belongs to the Section Cancer Therapy)
Disparities in Thoracic Oncology Patients
edited by Jeffrey B. Velotta and
submission deadline 30 Nov 2025 | Viewed by 329
Keywords: lung cancer; disparities; thoracic oncology
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition) submission deadline 30 Nov 2025 | Viewed by 259
Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials
(This special issue belongs to the Section Molecular Cancer Biology)
New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 254
Keywords: transcription factors; cancer treatment; degraders; inhibitors
(This special issue belongs to the Section Cancer Therapy)
Integrin Beta-1 Signaling in Cancers
edited by Adama Sidibé and Bernhard Wehrle-Haller
submission deadline 30 Nov 2025 | Viewed by 167
Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies
edited by Ganji P. Nagaraju and
submission deadline 1 Dec 2025 | 3 articles | Viewed by 9758 | Submission Open
Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Studies in Gastrointestinal Malignancies submission deadline 1 Dec 2025 | 4 articles | Viewed by 7702 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Post-transcriptional Regulation of Cancer-Related Processes
edited by
submission deadline 1 Dec 2025 | 1 articles | Viewed by 3556 | Submission Open
Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies
(This special issue belongs to the Section Tumor Microenvironment)
Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology submission deadline 5 Dec 2025 | 5 articles | Viewed by 13050 | Submission Open
Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects
(This special issue belongs to the Section Tumor Microenvironment)
Mesothelioma—from Diagnosis to Treatment
edited by
submission deadline 5 Dec 2025 | 4 articles | Viewed by 11291 | Submission Open
Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1
(This special issue belongs to the Section Cancer Therapy)
Paradigm Shifts in Gynaecological Oncology Surgery
edited by
submission deadline 5 Dec 2025 | 3 articles | Viewed by 6270 | Submission Open
Keywords: gynecological surgery; genomics risk management; survivorship health economics
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy
edited by and Julian Vivian
submission deadline 5 Dec 2025 | 2 articles | Viewed by 3984 | Submission Open
Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Clinical Research on Thoracic Cancer
edited by and Hiroyuki Adachi
submission deadline 6 Dec 2025 | 3 articles | Viewed by 6165 | Submission Open
Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation
(This special issue belongs to the Section Clinical Research of Cancer)
Preclinical and Clinical Research on the Efficacy of Anticancer Drugs
edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica
submission deadline 10 Dec 2025 | 2 articles | Viewed by 6760 | Submission Open
Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics
(This special issue belongs to the Section Clinical Research of Cancer)
New Advances in Oncology Research and Practice
edited by
submission deadline 10 Dec 2025 | 1 articles | Viewed by 1444 | Submission Open
Keywords: cancer bioinformatics; cancer biology; cancer diagnosis; cancer genomics; cancer immunotherapy; corona virus and cancer; cancer molecular mechanisms; organ-specific cancers; palliative cancer care
(This special issue belongs to the Section Cancer Therapy)
The Impact of Treatment Resistance in Prostate Cancer
edited by
submission deadline 10 Dec 2025 | Viewed by 208 | Submission Open
Keywords: prostate cancer; treatment resistance; progression; drug target; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Diagnosis of Hematologic Malignancies: 2nd Edition submission deadline 10 Dec 2025 | Viewed by 163 | Submission Open
Keywords: diagnosis of hematologic malignancies; myeloid neoplasms; lymphoid neoplasms; cytomorphology; flow cytometry; cytogenetic; molecular biology
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Prostate Cancer Metastasis—Diagnosis and Treatment
edited by Arnulf Stenzl
submission deadline 12 Dec 2025 | 1 articles | Viewed by 1040 | Submission Open
Keywords: prostate cancer; metastasis; hormone-sensitive; castration-resistant prostate cancer; imaging; PSMA; ligand therapy; sequence; oligometastatic; biomarker
(This special issue belongs to the Section Cancer Metastasis)
Clinical Treatment and Prognostic Factors of Urologic Cancer
edited by
submission deadline 15 Dec 2025 | 13 articles | Viewed by 37057 | Submission Open
Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment
(This special issue belongs to the Section Cancer Therapy)
New Biomarkers in Cancers 2nd Edition
edited by
submission deadline 15 Dec 2025 | 13 articles | Viewed by 30552 | Submission Open
Keywords: cancer; biomarker; molecule; serum; tumor; liquid biopsy; circulating tumor DNA; DNA; RNA; protein; circulating tumor cells; prognosis; prediction; indicator; traceable substance
(This special issue belongs to the Section Cancer Biomarkers)
Biomarkers for Treatment Prediction, Prognosis and Early Detection of Gynecologic Cancer
edited by Brian S Finkelman, Rachelle P Mendoza and Hani Katerji
submission deadline 15 Dec 2025 | 10 articles | Viewed by 22389 | Submission Open
Keywords: biomarkers; endometrial cancer; uterine cancer; cervical cancer; ovarian cancer; vulvar cancer; treatment prediction; prognosis; early detection
(This special issue belongs to the Section Cancer Biomarkers)
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