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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in the Treatment of Pediatric Solid Tumors

edited by

Myriam Weyl Ben-Arush

and Oz Mordechai

submission deadline 20 Nov 2025 | 3 articles | Viewed by 7624 | Submission Open

Keywords: pediatric oncology; solid tumors; precision medicine; immunotherapy; artificial intelligence; innovative therapies

(This special issue belongs to the Section Pediatric Oncology)

Cancer Treatment: Present and Future of Radioligand Therapy

edited by

Egesta Lopci

and

Akram N. Al-Ibraheem

submission deadline 20 Nov 2025 | 2 articles | Viewed by 6752 | Submission Open

Keywords: radioligand therapy; PRLT; FAPI; PSMA; CXCR4; GRPR; GLP-1R; RLT; novel radiopharmaceutical; cancer theranostics

(This special issue belongs to the Section Cancer Therapy)

Thyroid Cancer: New Advances from Diagnosis to Therapy: 2nd Edition

edited by

Michael Kreißl

submission deadline 20 Nov 2025 | 5 articles | Viewed by 5664 | Submission Open

Keywords: thyroid scintigraphy; thyroid nodules; thyroid cancer; multikinase inhibitors; precision oncology; radioiodine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors (2nd Edition)

edited by Nuria Romero-Laorden

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5015 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; biomarkers; immune biomarkers; PD-L1; TMB; solid tumors

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Aberrant Cytokine Receptor Signaling in Hematological Cancers and Proliferative Disorders

edited by

Alister C. Ward

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1201 | Submission Open

Keywords: cytokine receptor; signaling; leukemia; lymphoma; myeloproliferative neoplasm; hematology; oncology

(This special issue belongs to the Section Tumor Microenvironment)

Salivary and Tissue Biomarkers in Head and Neck Cancers: Diagnostic and Prognostic Role

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Nov 2025 | Viewed by 209 | Submission Open

Keywords: head and neck cancer; biomarker; early diagnosis and prognosis

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 21 Nov 2025 | 1 articles | Viewed by 2337 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)

edited by

Shihori Tanabe

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3932 | Submission Open

Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Trials of Sarcoma

edited by Patrick Schlegel

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2010 | Submission Open

Keywords: cancer; sarcoma; clinical trial

Neurosurgical Advances in Brain Tumor Surgery

edited by Camilla Bonaudo, Alessandro Della Puppa and

Antonello Grippo

submission deadline 28 Nov 2025 | 2 articles | Viewed by 3185 | Submission Open

Keywords: brain lesions/tumors; preoperative mapping; neuro-oncology; navigated TMS (n TMS); brain stimulation; optical imaging; cognitive mapping; awake surgery; functional mapping; functional preservation; intraoperative monitoring; neurophysiological monitoring

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Brachytherapy in the Treatment of Tumors

edited by

Hideya Yamazaki

submission deadline 30 Nov 2025 | 12 articles | Viewed by 35717 | Submission Open

Keywords: brachytherapy; LDR; HDR; PDR; cervical cancer; prostate cancer; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Approaches for Cancer Treatment

edited by

Marzia Bruna Gariboldi

submission deadline 30 Nov 2025 | 13 articles | Viewed by 33864 | Submission Open

Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Radiomics and Imaging in Cancer Analysis

edited by

Marco Bertolini

and

Lidia Strigari

submission deadline 30 Nov 2025 | 13 articles | Viewed by 26339 | Submission Open

Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in the Management of Hematologic Malignancy

edited by Mohammad S. Hossain

submission deadline 30 Nov 2025 | 6 articles | Viewed by 22669 | Submission Open

Keywords: allo/auto HSCT; GvHD; immunotherapy; viral infection; hematologic malignancy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 30 Nov 2025 | 2 articles | Viewed by 19746 | Submission Open

Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | 11 articles | Viewed by 14521 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Sarcoma: Clinical Trials and Management

edited by

Mohammed M. Milhem

and

John Rieth

submission deadline 30 Nov 2025 | 6 articles | Viewed by 13939 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Surgical Approaches for Gynecological Cancers

edited by

Anna Myriam Perrone

and

Camelia Alexandra Coada

submission deadline 30 Nov 2025 | 9 articles | Viewed by 13060 | Submission Open

Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins

(This special issue belongs to the Section Cancer Therapy)

The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives

edited by

Debora Capelli

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11912 | Submission Open

Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1

(This special issue belongs to the Section Tumor Microenvironment)

Immune Landscape of Renal Cell Carcinoma

edited by

Scott S. Tykodi

and Yuexin Xu

submission deadline 30 Nov 2025 | 4 articles | Viewed by 11738 | Submission Open

Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions

edited by Yongwoo Dave Seo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 11072 | Submission Open

Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design

(This special issue belongs to the Section Cancer Therapy)

Advances in Esophageal Cancer Treatment

edited by

B.P.L. (Bas) Wijnhoven

Richard Skipworth

, Pieter Van der Sluis and

Tania Triantafyllou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 10522 | Submission Open

Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Novel Advances in Surgery for Prostate Cancer

edited by

Vincenzo De Marco

submission deadline 30 Nov 2025 | 3 articles | Viewed by 9591 | Submission Open

Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Research on Fluorescence-Guided Surgery in Cancer Treatment

edited by

Julius Höhne

submission deadline 30 Nov 2025 | 4 articles | Viewed by 9495 | Submission Open

Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Solid Cancers: Current and Future Landscape

edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8855 | Submission Open

Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell

(This special issue belongs to the Section Cancer Therapy)

Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging

edited by Andra Valentina Krauze

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7833 | Submission Open

Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations

(This special issue belongs to the Section Methods and Technologies Development)

Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)

edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7312 | Submission Open

Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 30 Nov 2025 | 2 articles | Viewed by 7068 | Submission Open

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice

edited by Xiaotong Song

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5288 | Submission Open

Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4895 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research of Cancer)

Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis (2nd Edition)

edited by

Carl-Henrik Heldin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4625 | Submission Open

Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer

edited by

Giovanni Crisafulli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4389 | Submission Open

Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Surgical Treatment of Spinal Tumors

edited by Daniel Lubelski

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3823 | Submission Open

Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life

(This special issue belongs to the Section Cancer Therapy)

Tissue-Agnostic Drug Development in Cancer (2nd Edition)

edited by Shivaani Kummar and

Kyaw Thein

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3698 | Submission Open

Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine

(This special issue belongs to the Section Cancer Drug Development)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3507 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Image Analysis and Machine Learning in Cancers: 2nd Edition

edited by

Helder C. R. De Oliveira

and

Arianna Mencattini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3057 | Submission Open

Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network

(This special issue belongs to the Section Methods and Technologies Development)

Calcium Signaling in Cancer Cell Progression

edited by

Amantini Consuelo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2742 | Submission Open

Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Tumor Microenvironment in Primary Liver Cancer 2nd edition

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2588 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2292 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1936 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Epigenetics in Cancer and Drug Therapeutics

edited by Bethsebie Sailo and Anup R. Sharma

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1929 | Submission Open

Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1904 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers

edited by

Francesco Tonelli

and

Enrico Mini

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1883 | Submission Open

Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Castration-Resistant Prostate Cancer Treatment

edited by

Eswar Shankar

and

Balaji Chandrasekaran

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1796 | Submission Open

Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination

(This special issue belongs to the Section Cancer Therapy)

Surgery in Metastatic Cancer (2nd Edition)

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1291 | Submission Open

Keywords: metastatic cancer; surgery; metastasectomy; indication; timing

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by Cesare Guida and Ida D'Onofrio

submission deadline 30 Nov 2025 | 1 articles | Viewed by 989 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Epstein-Barr Virus-Associated Cancers: From Pathogenesis to Treatment (2nd Edition)

edited by

Kwok-Wai Lo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 967 | Submission Open

Keywords: EBV; lymphomas; Burkitt lymphoma; Hodgkin lymphoma; NK/T cell lymphoma; nasopharyngeal carcinoma; gastric cancer; biomarkers; immunotherapy; targeted therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Clinical and Surgical Therapy for Colorectal Cancer

edited by Laura Koskenvuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 811 | Submission Open

Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Genetics of Sarcomas

edited by Wei Jiang

submission deadline 30 Nov 2025 | Viewed by 494 | Submission Open

Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification

(This special issue belongs to the Section Molecular Cancer Biology)

Mesothelioma: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 30 Nov 2025 | Viewed by 378 | Submission Open

Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy

(This special issue belongs to the Section Cancer Therapy)

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