Current Concept and Management of Pediatric ATRTs—2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 51
Special Issue Editors
2. Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Interests: pediatric neurosurgery; tumors of brain and nervous system; congenital CNS malformations; hydrocephalus; neuro-oncology; developmental biology; spine and spinal cord tumors; spinal tumors
Special Issues, Collections and Topics in MDPI journals
Interests: pediatric neuro-oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of a previous one, entitled "Current Concept and Management of Pediatric ATRTs" (https://www.mdpi.com/journal/cancers/special_issues/K71523QG63).
Atypical teratoid rhabdoid tumors (ATRTs) are CNS tumors that primarily affect infants and young children. They are fast-growing, invasive tumors with a high propensity for CSF disseminations. ATRTs occur in every location in the brain and spinal cord and present with a high case mortality following current treatment modalities.
Since their first description by Rorke in 1995, the histogenesis of ATRTs has remained an enigma. Due to the expression of neural, epithelial, and mesenchymal markers, they likely derive from pluripotent fetal cells. Based on genetic and DNA methylation status and transcriptome profiles, ATRTs are further divided into three distinct molecular subgroups: ATRT-SHH, ATRT-TYR, and ATRT-MYC; further subclassifications have also been proposed. The WHO Classification of CNS tumors has included ATRTs in “Embryonal Tumors”. ATRTs are distinct from other embryonal tumors in their clinical presentation, tumor location, imaging characteristics, and prognosis. ATRTs often represent a surgical challenge as treatment requires removing a deep-seated large vascular mass from young patients. They are often resistant to conventional chemotherapy. Radiation therapy, which is imperative, raises serious concerns with regard to effects on the developing CNS of young patients. Safe and effective therapeutic measures are urgently needed.
This Special Issue will highlight recent advances in the biological understanding and clinical management of ATRTs derived from preclinical, translational, and/or clinical investigations. The results of innovative diagnostic modalities (molecular and imaging) will be included. Descriptions of results from case series or multi-center group studies are encouraged for a better understanding of the clinical behavior of these tumors. Reports of advanced surgical techniques for resection, as well as adjuvant therapy including novel molecular-targeted therapy and/or immunotherapy, are welcome.
Prof. Dr. Tadanori Tomita
Dr. Alicia C. Lenzen
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- atypical teratoid rhabdoid tumors (ATRTs)
- CNS tumor
- embryonal tumors
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