Clinical Applications of Molecular Subtyping of Pancreatic Cancer

Dear Colleagues,

Pancreatic cancer is one of the biggest oncological and surgical challenges, for pancreatic malignancies are the fourth leading cause of death in adults and cause an estimated loss of 600,000–915,000 quality-adjusted life years (QALYs). Aggressive tumor growth and late diagnosis are primarily responsible for unfavorable prognosis, and although survival rate has improved in recent decades, it continues to remain low for patients with advanced pancreatic disease. With the evolution of genomics, next generation and whole genome sequencing, we now have an opportunity to tackle the aggressive growth and expansion of pancreatic tumors using novel techniques that might enable personalized treatment of pancreatic cancer patients. Utilization of a molecular taxonomy of pancreatic cancer will inform preclinical and clinical decision-making and assist in the development of novel therapeutic interventions.

This Special Issue is dedicated to publishing research centered around the developments in molecular subtyping of pancreatic cancer, whether related to a novel method, a transcriptomic subtype method or single gene alteration. Research on the practical applications of molecular subtyping in clinical practices, such as decision-making in surgical approaches, correlations with postoperative outcomes, administration of chemotherapy and long-term response, are encouraged. Future perspectives of genome-based subtyping will also be considered, especially regarding pancreatic transplantation where in vivo models of pancreatic transplantation have revealed progression and alteration of PDAC molecular subtypes. Therefore, we cordially invite researchers with experience in the MDT approach for the treatment of pancreatic diseases to share their invaluable insights.

In this Special Issue, original research articles, reviews,  and expert opinions are welcome. Research areas may include (but are not limited to) the following:

• Implications of pancreatic molecular cancer in pancreatic surgery;
• Association of postoperative outcomes in different molecular subtypes;
• Response to systematic therapy according to molecular subtypes;
• Implications of pancreatic transplant in genomic changes;
• Use of NGS in pancreatic cancer specimens;
• Personalized decision-making based on molecular subtyping;
• New advancements in targeted treatment strategies.

We look forward to receiving your contributions.

Prof. Dr. Ioannis C. Maroulis
Guest Editor

Manuscript Submission Information

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• pancreatic cancer
• pancreatic adenocarcinoma
• genomic subtyping
• transcriptomics
• next generation sequencing
• pancreatic surgery
• pancreatic transplantation