Immunohistochemistry in Translational Research and Diagnostics of Breast Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 549
Special Issue Editors
Interests: translational research; breast cancer; cancer cell biology; tumour microenvironment (TME); biomarkers; FGF–FGFR signalling
Interests: oncology; pathology; breast cancer; biostatistics; biomarkers; cell cycle; machine learning; artificial intelligence; FGF–FGFR signalling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human breast cancer (BC) represents a spectrum of tumour subtypes with distinct geno- and phenotypes, natural history and responsiveness to therapy. Although several molecular platforms based on transcriptional profiles have been developed in an attempt to capture and translate this diversity into clinical practice, routine immunohistochemistry still lies at the core of treatment decision making in BC patients. Available survival analyses and clinical data on acquired and/or de novo resistance to therapy indicate, however, that this commonly used, well-established diagnostic tool requires significant tuning. New immunohistochemical markers that will provide criteria for better stratification of patients for specific targeted therapies are urgently needed. The focus of this Special Issue is, therefore, hypothesis-driven research of molecular mechanisms of BC that might result in identification of such biomarkers. Original reports on mechanistic studies of molecular regulators of BC progression and resistance to currently available therapies, evaluating their clinical value as potential subtype-specific immunohistochemical markers of prognosis and prediction in BC, are particularly welcome.
We also invite articles and timely reviews on related topics such as:
- Tumour microenvironment (TME) in BC, its molecular components and immunotherapy
- Cell signalling
- Artificial intelligence and machine learning
- Digital pathology
- Inter- and intratumoural heterogeneity of BC
- Diagnostic techniques, which may serve as valid counterparts for immunohistochemistry in clinic
Dr. Hanna M. Romanska
Dr. Marcin Braun
Guest Editors
Manuscript Submission Information
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Keywords
- breast cancer
- immunohistochemistry
- biomarker
- prognosis
- cell signalling
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