Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 59
Special Issue Editor
Interests: radiation therapy; breast cancer; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer treatment is rapidly evolving with a growing emphasis on personalized care. The SOUND trial, for instance, is exploring whether ultrasound can safely replace axillary surgery in certain patients, potentially sparing them from unnecessary procedures. In the neoadjuvant setting, the NSABP B-51 trial suggests that radiotherapy could be reduced for patients who achieve a complete response to initial treatment. Other trials like IDEA, DEBRA, and MA.39 are investigating ways to reduce the intensity of treatment based on biological markers. Surgical advancements, such as targeted axillary dissection, focus on removing only specific cancerous lymph nodes, reducing complications like lymphedema. Meanwhile, radiotherapy is becoming more efficient with techniques that allow many patients to complete treatment in just five sessions, as seen in the FAST and FAST-FORWARD trials. Accelerated partial breast irradiation further personalizes care by targeting radiation to the tumor bed. These recent developments are reshaping breast cancer treatment and influencing guidelines like those from the National Comprehensive Cancer Network and the Choosing Wisely campaign, marking a significant shift towards more tailored, less invasive therapies.
Dr. Shengyang Peter Wu
Guest Editor
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Keywords
- biomarker-guided personalized breast treatment
- targeted axillary dissection
- neoadjuvant therapy
- local therapy
- radiotherapy reduction
- ultrahypofractionated partial breast irradiation
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