The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)

Dear Colleagues,

This Special Issue is the third edition of "The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion", following the success of the first edition (https://www.mdpi.com/journal/cancers/special_issues/TMMIE) and the second edition, “Volume II” (https://www.mdpi.com/journal/cancers/special_issues/4BPEBEU010).

It is widely recognized that the complex interplay between immunity and cancer determines whether cancer cells survive or are destroyed. The balance between tumoricidal and tumor-promoting activity depends on the strength of the antitumor immune response. In general, immune evasion mechanisms employed by cancers include downregulation of antigen presentations or recognition, depletion of immune effector cells, blockade immune cell maturation, accumulation of immunosuppressive cells, production of inhibitory cytokines, chemokines, or ligands/receptors, establishment of a hypoxic tumor microenvironment, activation of cancer-promoting metabolic pathways, and upregulation of immune checkpoint modulators.

Restoring or stimulating tumoricidal effects—together surgical resection, chemotherapy, radiotherapy, hormone-based therapies, kinase inhibitors, DNA repair disruptors, small=molecule inhibitors, signal transduction pathway modifiers, epigenome reprogramming, and cytokine-based treatments—may enable promising therapeutic regimens to eradicate aggressive cancers. This Special Issue welcomes papers that elucidate mechanisms of immune escape or propose strategies for enhancing immune surveillance, particularly in combination with non-immune interventions to eradicate human cancers.

Dr. Huey-Jen Lin
Guest Editor

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