The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 September 2026
Special Issue Editor
Interests: DNA methylation; cancer invasion and metastasis in breast and pancreatic cancers; carcinoma-associated fibroblasts; epithelial–mesenchymal transition; AKT signaling pathway; tumor microenvironment and immune evasion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the third edition of "The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion", following the success of the first edition (https://www.mdpi.com/journal/cancers/special_issues/TMMIE) and the second edition, “Volume II” (https://www.mdpi.com/journal/cancers/special_issues/4BPEBEU010).
It is widely recognized that the complex interplay between immunity and cancer determines whether cancer cells survive or are destroyed. The balance between tumoricidal and tumor-promoting activity depends on the strength of the antitumor immune response. In general, immune evasion mechanisms employed by cancers include downregulation of antigen presentations or recognition, depletion of immune effector cells, blockade immune cell maturation, accumulation of immunosuppressive cells, production of inhibitory cytokines, chemokines, or ligands/receptors, establishment of a hypoxic tumor microenvironment, activation of cancer-promoting metabolic pathways, and upregulation of immune checkpoint modulators.
Restoring or stimulating tumoricidal effects—together surgical resection, chemotherapy, radiotherapy, hormone-based therapies, kinase inhibitors, DNA repair disruptors, small=molecule inhibitors, signal transduction pathway modifiers, epigenome reprogramming, and cytokine-based treatments—may enable promising therapeutic regimens to eradicate aggressive cancers. This Special Issue welcomes papers that elucidate mechanisms of immune escape or propose strategies for enhancing immune surveillance, particularly in combination with non-immune interventions to eradicate human cancers.
Dr. Huey-Jen Lin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CD8+ tumor-infiltrating lymphocytes
- cytotoxic T lymphocytes -associated protein 4
- dendritic cells
- immune evasion
- hypoxia-inducible factors
- myeloid-derived suppressor cells
- natural killer
- programmed death receptor and ligand
- regulatory T cells
- tumor-associated macrophages
- tumor microenvironment
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