The Role of Nutrients in Cancer Progression
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 49
Special Issue Editor
Interests: cancer epidemiology; infection and cancer; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
While the role of diet and nutrition in human cancer incidence has been well established, there are limited data to support the role of individual nutrients in disease progression among cancer patients. Importantly, while the survival and proliferation of cells are dictated by nutrient availability, the nutrient demands of cancer cells are often different from those of noncancerous cells. Thus, cancer cell survival and proliferation may be limited by different metabolic factors than those required for noncancerous cells, which may be imposed by mutations that drive tumor progression. Accordingly, nutritional factors that play role in cancer progression are likely to be different from those involved in cancer initiation and may further vary with molecular subtypes or metabolic signatures of individual cancer. In addition, several dietary constituents, such as phytochemicals and fiber, have been shown to influence sensitivity to cancer treatments. However, there are currently limited data to support the role of specific nutrient intake/supplementation/deprivation in modulating cancer outcomes, which encompass recurrence, metastasis, cancer-specific mortality, and response to cancer-targeted treatments, e.g., radiation, chemotherapy, immunotherapy, and endocrine therapy.
This Special Issue of Cancers, therefore, aims to present recent progress in research that addresses how specific nutrient intake/supplementation/deprivation (after cancer diagnosis/development/ implantation) affects cancer outcomes in humans or in animals, modulates key oncogenic signaling pathways linked to cancer progression, and alters in vitro treatment sensitivity. The information submitted to this collection will help design new nutritional interventions to improve patient outcomes from cancer therapies. We invite both original research articles and comprehensive reviews, including in vitro studies, animal models, clinical trials, and observational studies. Please note that manuscripts consisting solely of bioinformatics or computational analyses of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this Special Issue.
I look forward to receiving your contributions.
Prof. Dr. Ikuko Kato
Guest Editor
Manuscript Submission Information
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Keywords
- vitamins
- phytochemicals
- trace minerals
- ketogenic diet
- cancer recurrence
- cancer metastasis
- treatment response
- radiotherapy
- chemotherapy
- immunotherapy
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