Oncogenetics of Colorectal Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 271
Special Issue Editors
2. Department of Public Health Sciences, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
Interests: colorectal carcinoma; microsatellite instability; cytogenetics; molecular genomics; GWAS; copy number change; telomere; methylation; liquid biopsy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Colorectal carcinoma (CRC) is one of the most common cancers worldwide. It represents a heterogeneous group of disorders from a molecular genomic point of view. Sporadic CRC is the most common form and is associated with somatic mutations, DNA methylation, genomic instability in the form of copy number changes, and microsatellite instability. Inflammatory pathways and host immune response have been associated not only with pathogenesis but also targeted therapeutic options. Many of the changes occurring are also reflected in liquid biopsy samples. Full use of known and yet-to-be-known molecular changes in the tumor tissue and/or liquid biopsy for predictive, diagnostic, therapeutic, and prognostic purposes could improve personalized therapy.
This Special Issue aims to focus on original research papers and review articles on different molecular genomic and epigenetic changes in CRC tissue and liquid biopsy and their association with the pathogenesis of CRC as well as therapeutic applications and outcomes.
Dr. Muhammad Kibriya
Dr. Marc Bissonnette
Guest Editors
Manuscript Submission Information
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Keywords
- colorectal carcinoma
- somatic mutation
- microsatellite instability
- methylation
- copy number change
- tumor-infiltrating leukocyte
- immune checkpoint inhibitor
- drug resistance
- cell-free DNA
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