Spatio-Temporal Changes in the Tumor Microenvironment: Focus on Hypoxia, Acidosis and Metabolism
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (1 October 2023) | Viewed by 260
Special Issue Editors
Interests: microenvironment; acidosis; hypoxia; lipid metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A tumor is made up of cancer cells and a heterogeneous collection of infiltrating and resident host cells, extracellular matrices and secreted factors. The ecosystem surrounding these players is also characterized by physicochemical alterations when compared with the hosting tissue. Today, hypoxia and acidosis are recognized as two major hallmarks of the tumor microenvironment (TME). Areas of low O2 and low pH develop in tumors because of the heterogeneous perfusion and metabolic preferences of the different constituent cell populations. Spatial alteration is the most common picture seen in these TME components, as underlined by the widespread use of the wording “gradients of O2, H+, metabolites or nutrients” in the literature. Temporal fluctuations are less widely described, although TME dynamics have been known for decades by investigators working on cycling or intermittent hypoxia. Circadian rhythms are actually rarely associated with TME, since clock disruption is usually associated with the onset of cancers in response to genetic and lifestyle risk factors. However, as day/light alternation and meals influence our central and peripheral clocks, tumor metabolism is inevitably influenced by fluctuations in the availability of nutrients and even circulating hormones, such as insulin. Spatiotemporal fluctuations in tumor metabolism thus further emphasize that TME is not a silent bystander but a key player in tumor growth.
In this Special Issue of Cancers, we welcome original research articles and review articles focusing on spatial specificities and time-dependent oscillations in cellular phenotypes and metabolic preferences within TME and how these parameters may offer a new framework for the discovery of innovative anticancer strategies.
Prof. Dr. Olivier Feron
Dr. Léo Aubert
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hypoxia
- acidosis
- tumor microenvironment
- cancer
- metabolism
- circadian rhythm
- clock gene
- anticancer drugs
- spheroids
- organoids
