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Cancers
Special Issues
Recent Advances in Non-Small Cell Lung Cancer
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Recent Advances in Non-Small Cell Lung Cancer

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (15 May 2018) | Viewed by 48299

Special Issue Editor

Prof. Dr. Siow Ming Lee

E-Mail Website
Guest Editor
Department of Oncology, University College Hospital, 250 Euston Road, London NW1 2PG, UK
Interests: lung cancer; HIV-related cancers; lymphoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Significant progress has been made in the field of targeted treatment, immunotherapy and cancer biology since our last Special Issue in 2015 on “Non-Small Cell Lung Cancer Therapies”. After decades of disappointment, cancer immunotherapy treatment has finally come of age, especially with the ability of anti-PD-1 and anti-PD-L1 agents to significantly improve treatment outcome as first- and second-line agents over standard chemotherapy treatment in advanced Non-Small Cell Lung Cancer (NSCLC). In addition, durvalumab, an anti-PD-L1 agent, when used as adjuvant treatment after chemo radiotherapy treatment in stage III NSCLC, was also found to improve outcomes. There were also significant developments seen in the field of targeted treatment. Newer generation targeted TKI agents, osimertinib and alectinib were significantly found to be superior compared to the first-generation agents, with a doubling of PFS outcome. They also have substantial clinical activity against brain metastases. In the field of cancer biology, the TRACERx consortium based in the UK published the first results of their 100 recruited patients which have provided new insights how lung cancer evolves with implications for possible new targeted and immunotherapy for the future.

This Special Issue aims to summarize and update researchers and clinicians as to the remarkable progress made in the field of targeted therapy, immunotherapy and cancer biology made recently for lung cancer.

Prof. Dr. Siow Ming Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NSCLC
  • immunotherapy
  • EGFR TKIs
  • ALK inhibitors
  • tumor heterogeneity
  • circulating tumor DNA

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Published Papers (8 papers)

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8 pages, 202 KiB  
Perspective
Surgical Resection Versus Stereotactic Body Radiation Therapy for Stage I NSCLC: Can Randomized Trials Provide the Solution?
Cancers 2018, 10(9), 310; https://doi.org/10.3390/cancers10090310 - 4 Sep 2018
11 pages, 2222 KiB  
Article
Stereotactic Body Radiation Therapy for Patients with Pulmonary Interstitial Change: High Incidence of Fatal Radiation Pneumonitis in a Retrospective Multi-Institutional Study
Cancers 2018, 10(8), 257; https://doi.org/10.3390/cancers10080257 - 2 Aug 2018
17 pages, 255 KiB  
Review
Role of Immunotherapy for Oncogene-Driven Non-Small Cell Lung Cancer
Cancers 2018, 10(8), 245; https://doi.org/10.3390/cancers10080245 - 27 Jul 2018
22 pages, 279 KiB  
Review
A Review of Recent Advances in the Treatment of Elderly and Poor Performance NSCLC
Cancers 2018, 10(7), 236; https://doi.org/10.3390/cancers10070236 - 18 Jul 2018
17 pages, 1665 KiB  
Review
Current Molecular-Targeted Therapies in NSCLC and Their Mechanism of Resistance
Cancers 2018, 10(7), 224; https://doi.org/10.3390/cancers10070224 - 4 Jul 2018
11 pages, 1264 KiB  
Review
Measuring Surgery Outcomes of Lung Cancer Patients with Concomitant Pulmonary Fibrosis: A Review of the Literature
Cancers 2018, 10(7), 223; https://doi.org/10.3390/cancers10070223 - 4 Jul 2018
16 pages, 584 KiB  
Review
Radiation Pneumonitis: Old Problem, New Tricks
Cancers 2018, 10(7), 222; https://doi.org/10.3390/cancers10070222 - 3 Jul 2018
16 pages, 1509 KiB  
Review
Understanding Intratumor Heterogeneity and Evolution in NSCLC and Potential New Therapeutic Approach
Cancers 2018, 10(7), 212; https://doi.org/10.3390/cancers10070212 - 22 Jun 2018
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