Biocatalysis: Mechanisms of Proteolytic Enzymes
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 9464
Special Issue Editor
Interests: protein crystallography, proteases, kallikrein-related peptidases, metalloproteinases, enzyme kinetics, inhibitors, gylcosylation, human physiology, protein folding
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteases are traditionally among the most studied enzymes and over the decades a wealth of structural, functional and theoretical information has accumulated. However, the understanding of the molecular mechanisms underlying their activities and regulation remains incomplete. Although the basic principles of peptide bond hydrolysis were delineated a long time ago, there is a lack of experimental evidence for many aspects of substrate recognition, turnover, energetics, time course of the catalytic steps, and of the fine-tuned physiological regulation of activity. Thus, it is worth investigating and comparing the molecular mechanisms for the numerous serine, cysteine, metallo and aspartic proteases, as well as for the much rarer threonine, asparagine and glutamic type. In order to add more biological and medical relevance, we welcome articles that analyze molecular interactions of proteases with natural substrates and inhibitors or their synthetic small molecule counterparts.
The goal of this Special Issue is to present experimental, computational and comparative studies, which promote a deeper understanding of the common mechanistic principles of proteases. Also, structural and analytical data from crystallography, cryo-EM, NMR and MS that support functional and mechanistic research are welcome. Therefore, submissions to this Special Issue on the “Biocatalysis: Mechanisms of Proteolytic Enzymes” should be either original research papers, including short communications, or reviews and perspectives. Eventually, we hope to draw a topical picture of the current status and developments, which could have an impact on other fields of research, such as medicine and pharmacy.
Accepted papers are published in the joint Special Issue in Catalysts or International Journal of Molecular Sciences.
Dr. Peter Goettig
Guest Editor
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Keywords
- aspartic proteases
- catalytic mechanism
- conformational selection
- cysteine proteases
- enzyme kinetics
- metalloproteases
- nucleophilic attack
- peptide bond hydrolysis
- serine protease
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