Aging and Metabolic Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 2842
Special Issue Editor
Interests: mtorc1; autophagy; pancreatic beta cells; diabetes; mitophagy; tsc2; er-stress; MVB; exosomes; aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Different metabolic diseases, including T2DM and obesity, are two related and progressive diseases that represent a major public health problem in our modern society, contributing to alteration in the balance between a healthy situation and an unhealthy situation. Both pathologies share several characteristics, including insulin resistance, hyperactivation of the mTORC1 signaling pathway, a low grade of inflammation, and an aged phenotype. One of the earliest pathophysiological features is insulin resistance, followed by a compensatory mechanism in pancreatic islets, which turns out to manifest hyperinsulinemia. The sustained secretion of pancreatic insulin constrains the incipient glucose intolerance in the second stage of type 2 diabetes progression. However, this compensatory mechanism finally fails, resulting in a full-blown phenotype. In addition to the changes previously mentioned, there are several alterations including mitochondrial dysfunction, dysfunctional autophagy, and an increase in oxidative stress. Different strategies have been studied in order to ameliorate all of these circumstances, such as calorie restriction, exercise, and intermittent fasting, among others, and could potentially modify the progression of the diseases, improving the free-disease period and potentiating a healthy life.
This Special Issue of Cells will highlight recent progress in aging and metabolic diseases through a collection of original research articles, reviews, and communications. We welcome all types of studies related to this topic to be submitted to this Special Issue.
Dr. Carlos Guillen
Guest Editor
Manuscript Submission Information
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Keywords
- aging
- insulin resistance
- diabetes
- obesity
- mitochondrial dysfunction
- beta-galactosidase
- senescent-associated secretory phenotype
- pancreatic beta cells
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