Recent Progress on Fibrosis and Cardiac Dysfunction
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 April 2025 | Viewed by 86
Special Issue Editors
Interests: cardiac regeneration; Arrhythmias
Interests: atherosclerosis; inflammation; antigen; antibodies; auto-antibodies; interleukin 5; B1 cell; B2 cell; spleen; tertiary lymphoid tissue
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiac fibrosis involves the thickening and stiffening of heart tissue due to excessive accumulation of extracellular matrix (ECM) components. This process disrupts the normal architecture and function of the myocardium, leading to cardiac dysfunction. Various factors, such as ischemic heart disease, hypertension, atrial fibrillation, and inflammatory diseases, can trigger the initial injury. In response, cardiac fibroblasts become activated and transform into myofibroblasts, producing excess ECM proteins, including collagen I and III. The accumulation of the ECM results in myocardial stiffening, disrupting the heart's normal electrical conduction and mechanical function.
Cardiac fibrosis is a critical area of research due to its significant impact on heart function and overall cardiovascular health. Current studies aim to uncover new mechanisms and treatments to better manage and potentially reverse this condition. This Special Issue aims to highlight recent findings on how preventing fibrosis can help preserve cardiac function at both cellular and organismal levels. Additionally, we welcome contributions that explore innovative technologies and methodologies that could pave the way for new therapeutic approaches.
Dr. Tabito Kino
Dr. Tomoaki Ishigami
Guest Editors
Manuscript Submission Information
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Keywords
- regeneration
- cardiac fibrosis
- cardiac dysfunction
- ischemic heart disease
- hypertension
- atrial fibrillation
- inflammation
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