Molecular Insight into Tubular Mechanism for Handling Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 6166
Special Issue Editor
Interests: hypertension; salt sensitivity; tubular transport; epithelial sodium channels; ubiquitination; Nedd4-2 and atherosclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney diseases (CKD) include end-stage kidney disease and cardiovascular disease, which are defined as a decrease in renal function calculated by estimated glomerular filtration ratio (eGFR) and chronically persistent (more than 3 months in duration) kidney involvements including proteinuria. Instead of the conventional pathological classification that emphasizes the etiology and pathophysiology of renal disease such as glomerulonephritis and glomerulosclerosis, disease control based on the concept of being medicalized as chronic kidney disease (CKD) is becoming more viable. Estimated GFR has made it possible to quantitatively assess medical conditions, but unlike blood pressure, lipids, and blood glucose, the treatments that specifically control GFR remain unresolved. For diabetes and hypertension, which are individual diseases that target the kidney, there are specific therapeutic means, and renal disorders will be resolved by providing treatment for the underlying disease. However, it is expected that only nutrition, metabolism, and lifestyle-related improvements are effective in eliminating CKD. Therefore, there is an urgent need to discover specific molecular targets which enable us to develop a new class of pharmaceutic procedures to treat CKD in medical settings.
Urinary tubules are highly differentiated human kidney tissues from the glomerulus to the collecting duct, through which urine passes and undergoes reabsorption and secretion of various solutes, ion, and organic acid by specific transporters and channels. Diuretics such as loop diuretics (NKCC2), thiazides (NCCT), amiloride (ENaC), and tolvaptan (AQP1) were developed to act on both sodium ion transporters and water channel, which are widely used for medical fields. Additionally, current advents for sodium glucose transporters are projected to be used to treat cardiac diseases, chronic heart failure, and chronic kidney diseases. Thus, renal tubules and tubular mechanisms have been and will continue to be important sources of drug discovery targets for the treatment of chronic kidney disease. In this Special Issue of the International Journal of Molecular Science, entitled “Molecular Insight into Tubular Mechanism for handling CKD (chronic kidney disease)”, we would like to invite your contributions in the form of either original research articles or reviews, which address the expanding field of mechanic, functional and pharmacological dissections about the physiological and pathological implications of urinary tubules for future medical inventories.
Dr. Tomoaki Ishigami
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
-
chronic kidney diseases
- kidney disease
- cardiovascular disease
- urinary tubules
- pharmacological
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
