Molecular Insight into Tubular Mechanism for Handling Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 5941
Special Issue Editor
Interests: hypertension; salt sensitivity; tubular transport; epithelial sodium channels; ubiquitination; Nedd4-2 and atherosclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney diseases (CKD) include end-stage kidney disease and cardiovascular disease, which are defined as a decrease in renal function calculated by estimated glomerular filtration ratio (eGFR) and chronically persistent (more than 3 months in duration) kidney involvements including proteinuria. Instead of the conventional pathological classification that emphasizes the etiology and pathophysiology of renal disease such as glomerulonephritis and glomerulosclerosis, disease control based on the concept of being medicalized as chronic kidney disease (CKD) is becoming more viable. Estimated GFR has made it possible to quantitatively assess medical conditions, but unlike blood pressure, lipids, and blood glucose, the treatments that specifically control GFR remain unresolved. For diabetes and hypertension, which are individual diseases that target the kidney, there are specific therapeutic means, and renal disorders will be resolved by providing treatment for the underlying disease. However, it is expected that only nutrition, metabolism, and lifestyle-related improvements are effective in eliminating CKD. Therefore, there is an urgent need to discover specific molecular targets which enable us to develop a new class of pharmaceutic procedures to treat CKD in medical settings.
Urinary tubules are highly differentiated human kidney tissues from the glomerulus to the collecting duct, through which urine passes and undergoes reabsorption and secretion of various solutes, ion, and organic acid by specific transporters and channels. Diuretics such as loop diuretics (NKCC2), thiazides (NCCT), amiloride (ENaC), and tolvaptan (AQP1) were developed to act on both sodium ion transporters and water channel, which are widely used for medical fields. Additionally, current advents for sodium glucose transporters are projected to be used to treat cardiac diseases, chronic heart failure, and chronic kidney diseases. Thus, renal tubules and tubular mechanisms have been and will continue to be important sources of drug discovery targets for the treatment of chronic kidney disease. In this Special Issue of the International Journal of Molecular Science, entitled “Molecular Insight into Tubular Mechanism for handling CKD (chronic kidney disease)”, we would like to invite your contributions in the form of either original research articles or reviews, which address the expanding field of mechanic, functional and pharmacological dissections about the physiological and pathological implications of urinary tubules for future medical inventories.
Dr. Tomoaki Ishigami
Guest Editor
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Keywords
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chronic kidney diseases
- kidney disease
- cardiovascular disease
- urinary tubules
- pharmacological
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