Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.9
5.1
Journals
Cells
Special Issues
Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease
share announcement

Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 3255

Special Issue Editors

Dr. Agnieszka Mikłosz

E-Mail Website1 Website2
Guest Editor
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland
Interests: obesity; mesenchymal stem cells; insulin resistance; diabetes mellitus; cardiovascular diseases; adipocytes; skeletal muscle; metabolic syndrome; lipid metabolism; fatty acid handling proteins, cellular metabolism
Special Issues, Collections and Topics in MDPI journals
Dr. Bartłomiej Łukaszuk

E-Mail Website
Guest Editor
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland
Interests: cellular physiology

Special Issue Information

Dear Colleagues,

The worldwide increase in the prevalence of obesity has raised the demand for new therapeutic strategies targeting the related chronic metabolic complications. Among different treatment options for obesity, mesenchymal stem cell (MSC) therapy attracts the most attention. The unique features of MSCs, including immunosuppressive and immunomodulatory properties, make them an ideal candidate for clinical applications. Numerous data have shown that MSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress. Nevertheless, the transplantation of mesenchymal stem cells is associated with certain risks; therefore, recently, much attention has been devoted to MSC derivatives, such as exosomes or conditioned media (CM), as therapeutic agents for the treatment of metabolic complications of obesity. MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.

This Special Issue aims to provide a comprehensive overview of the therapeutic potential of mesenchymal stem cells (MSCs) in the treatment of obesity-related metabolic complications such as type 2 diabetes mellitus (T2DM), insulin resistance (IR), hepatic steatosis, hepatic fibrosis, infertility, vascular disorders or systemic inflammation. Authors are invited to submit original articles, review articles or meta-analyses/systematic reviews with new insights into MSC-based therapy.

We look forward to your contributions.

Dr. Agnieszka Mikłosz
Dr. Bartłomiej Łukaszuk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes mellitus
  • dyslipidemia
  • insulin resistance
  • metabolic syndrome
  • mesenchymal stem cells
  • obesity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

24 pages, 3429 KiB  
Article
Altered Cytokine Secretory Fingerprint of the Adipocytes Derived from Stem Cells of Morbidly Obese Patients—A Preliminary Study
by Bartłomiej Łukaszuk, Elżbieta Supruniuk, Adrian Chabowski and Agnieszka Mikłosz
Cells 2024, 13(19), 1603; https://doi.org/10.3390/cells13191603 - 24 Sep 2024
Viewed by 1055
Abstract
Context: Adipose-derived mesenchymal stem cells (ADMSCs) are progenitor cells that shape the tissue’s biological properties. Objective: To examine the adipocytes differentiated from the ADMSCs of lean and obese individuals with/without a metabolic syndrome (MetSx) cytokine secretory profile, as to date, little is known [...] Read more.
Context: Adipose-derived mesenchymal stem cells (ADMSCs) are progenitor cells that shape the tissue’s biological properties. Objective: To examine the adipocytes differentiated from the ADMSCs of lean and obese individuals with/without a metabolic syndrome (MetSx) cytokine secretory profile, as to date, little is known on this topic. Methods: Interleukin, chemokine and growth factor levels in the culture medium were determined using the Human Cytokine kit. Results: We observed a characteristic secretory fingerprint displayed by the cells from the MetSx group and identified a set of putative markers (IL-1β, IL-6, IL-7, IL-10, IL-12, IL-13, VEGF, FGF, GM-CSF, TNF-α, IFN-γ) of the condition. Surprisingly, the concentrations of most of the molecules (except for IL-6, IFN-γ, IP-10, VEGF) decreased when compared with the cells from the lean group. We postulate that the difference stemmed from the fact that in vivo cytokines were mostly secreted by the activated monocytes/macrophages and not adipocytes per se. This may also suggest that the aforementioned upregulated cytokines (IL-6, IFN-γ, IP-10, VEGF) might have been the ones that attracted monocytes and triggered the vicious cycle of tissue inflammation. Conclusions: Our study indicated that the adipocytes newly derived from the ADMSCs of obese patients with metabolic syndrome displayed a secretory fingerprint that may be characteristic to the early stages of the condition. Full article
(This article belongs to the Special Issue Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease)
►▼ Show Figures

Figure 1

Review

Jump to: Research

19 pages, 506 KiB  
Review
Autologous Fat Grafting—A Panacea for Scar Tissue Therapy?
by Nura Ahmad, Alexandra Anker, Silvan Klein, Jillian Dean, Leonard Knoedler, Katya Remy, Andrea Pagani, Sally Kempa, Amraj Terhaag and Lukas Prantl
Cells 2024, 13(16), 1384; https://doi.org/10.3390/cells13161384 - 20 Aug 2024
Viewed by 1555
Abstract
Scars may represent more than a cosmetic concern for patients; they may impose functional limitations and are frequently associated with the sensation of itching or pain, thus impacting both psychological and physical well-being. From an aesthetic perspective, scars display variances in color, thickness, [...] Read more.
Scars may represent more than a cosmetic concern for patients; they may impose functional limitations and are frequently associated with the sensation of itching or pain, thus impacting both psychological and physical well-being. From an aesthetic perspective, scars display variances in color, thickness, texture, contour, and their homogeneity, while the functional aspect encompasses considerations of functionality, pliability, and sensory perception. Scars located in critical anatomic areas have the potential to induce profound impairments, including contracture-related mobility restrictions, thereby significantly impacting daily functioning and the quality of life. Conventional approaches to scar management may suffice to a certain extent, yet there are cases where tailored interventions are warranted. Autologous fat grafting emerges as a promising therapeutic avenue in such instances. Fundamental mechanisms underlying scar formation include chronic inflammation, fibrogenesis and dysregulated wound healing, among other contributing factors. These mechanisms can potentially be alleviated through the application of adipose-derived stem cells, which represent the principal cellular component utilized in the process of lipofilling. Adipose-derived stem cells possess the capacity to secrete proangiogenic factors such as fibroblast growth factor, vascular endothelial growth factor and hepatocyte growth factor, as well as neurotrophic factors, such as brain-derived neurotrophic factors. Moreover, they exhibit multipotency, remodel the extracellular matrix, act in a paracrine manner, and exert immunomodulatory effects through cytokine secretion. These molecular processes contribute to neoangiogenesis, the alleviation of chronic inflammation, and the promotion of a conducive milieu for wound healing. Beyond the obvious benefit in restoring volume, the adipose-derived stem cells and their regenerative capacities facilitate a reduction in pain, pruritus, and fibrosis. This review elucidates the regenerative potential of autologous fat grafting and its beneficial and promising effects on both functional and aesthetic outcomes when applied to scar tissue. Full article
(This article belongs to the Special Issue Multifaceted Roles of Mesenchymal Stem Cells in Health and Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop