Neuropathic Pain: From Mechanism to Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 829
Special Issue Editor
Interests: neuron; neurophysiology; electrophysiology; patch-clamp electrophysiology; synapses; synaptic plasticity; behavioral neuro-science; behavioral analysis; behavioral experiment
Special Issue Information
Dear Colleagues,
Neuropathic pain is caused by a lesion or diseases affecting the somatosensory system (IASP). It affects around 7–8% of the general population and represent 25% of chronic pain patients. Despite the research in the last 30 years, only a few and relatively poorly efficient molecules have been found to treat neuropathic pain with a huge translational failure rate. Most of the preclinical models focused on sensory neurotransmission, with a special emphasize on the first relay of nociceptive information, the dorsal horn of the spinal cord. Beyond alterations to nociceptive transmission, neuropathic pain is also accompanied by many associated comorbidities such as anxio-depressive disorders, anhedonia, and motor and cognitive deficits, which reflect the “pain matrix”. The emergence of cutting-edge techniques assessing specific neuronal circuits facilitate in-depth studies of the connections between the pain matrix circuits and the behavioral outputs. Pain behaviors are evaluated through reflex-induced responses and various complex behaviors to obtain the most complete vision of the painful state. In the coming years, this will provide new, promising therapeutic strategies.
In this Special Issue, we invite you to improve our current knowledge of neuropathic pain by contributing original research articles. Stimulating reviews that critically appraise or provide new interpretations of the extant literature are also welcome.
Prof. Dr. Pascal Fossat
Guest Editor
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