Molecular Pathways and Potential Therapeutic Targets of Vascular Dysfunction
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 131
Special Issue Editor
Interests: vascular dysfunction; protein homeostasis; diabetes; hypertension; DAMPS; low-grade inflammation; aging; ROS; arterial stiffness; erectile dysfunction; innate immunity; TLR4
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The vasculature is crucial in human homeostasis, and an intricate net of pathways and signaling molecules mediates its functionality. The players in this scenario are the endothelial and vascular smooth muscle cells lining the blood vessels. Disruption in the mechanisms driving these two cells’ functionality leads to vascular dysfunction, which is central to the origin and development of vascular damage. Vascular dysfunction encompasses an injured endothelium characterized by an imbalance between vasoconstrictor and vasodilatory factors, microvascular dysfunction, and large artery damage by remodeling and arterial stiffening.
Vascular dysfunction leading to damaged vessels affects the quality of life and remains the leading cause of disease burden worldwide. It is a hallmark of a multitude of pathological conditions, including diabetes, hypertension, pre-eclampsia, and coronary and cerebrovascular diseases. Yet, there is a lack of information about mitigating vascular damage, and many molecular pathways need further investigation. Likewise, many paradigms require discussion, such as the role of innate immune receptors in mediating vascular dysfunction or whether there is a link between arterial stiffness and vascular dysfunction. This Special Issue welcomes manuscripts focusing on any aspect of vascular dysfunction-associated molecular pathways to enhance scientific comprehension, mitigate vascular damage, and unveil new therapeutic avenues to treat this condition.
Dr. Kenia Pedrosa Nunes
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- vascular dysfunction
- endothelial dysfunction
- vascular remodeling
- arterial stiffness
- vascular signaling
- new vascular targets
