Oral Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5817
Special Issue Editors
2. Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA
Interests: oral cancer; oral cancer carcinogenesis and tumor progression; the neurobiological basis of oral cancer pain
Special Issue Information
Dear Colleagues,
Oral cancer is the most common type of head-and-neck cancer (HNC), which is a heterogeneous group of tumors that arise in the head-and-neck region. HNC affects over 890,000 people every year worldwide with a high prevalence in Southeast Asia, Brazil, and Southern Africa. Despite recent advances in oral cancer treatment, the overall survival rate remains stagnant (the median survival remains <1 year for patients with metastatic or recurrent HNC). The current treatment therapies are highly toxic, and efforts to improve the treatment efficacy have been largely disappointing. There is an urgent need for a better understanding of cellular and molecular mechanisms of the tumor and the development of more effective therapies to improve the treatment outcomes.
This Special Issue invites basic scientists and clinician scientists to share their recent discoveries and provide insights/updates focused on aspects of oral cancer mechanisms and therapeutics, including target identification and validation, biomarkers for the disease or treatment responses, the contribution of exosomes, immune cells, and other tumor stromal cells and stem cells in cancer progression and treatment resistance, biomaterials, precision medicine, improved traditional therapies (surgical, chemotherapies, radiation), biological therapies, immunotherapies, and other emerging mechanism-based therapies.
We look forward to your contributions.
Dr. Yi Ye
Dr. Hope M. Amm
Guest Editors
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Keywords
- squamous cell carcinoma
- invasion
- angiogenesis
- metastasis
- inflammation
- immune suppression
- stem cells
- epithelial–mesenchymal transition
- microbiome
- exosomes
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