Cellular and Molecular Events in Intervertebral Disc Development, Homeostasis and Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 January 2025 | Viewed by 420
Special Issue Editor
Special Issue Information
Dear Colleagues,
The healthy intervertebral disc (IVD) is an aneural, avascular, and immune-privileged fibrocartilaginous structure. It presents regionally distinct phenotypes with a unique microenvironment and cellular composition. Despite a characteristically poor cell density, each cell type is crucial for maintaining the specific extracellular microenvironment and plays a vital role in ensuring the functional and structural integrity of the IVD. However, the cellular and molecular characteristics of the IVD are critically influenced by various factors such as age, genetic, metabolic, and mechanical factors, which can significantly affect IVD development, homeostasis, and disease.
This Special Issue is dedicated to interesting and innovative research on “Cellular and Molecular Events in Intervertebral Disc Development, Homeostasis, and Disease”. Further, it includes novel approaches in regenerative medicine and tissue engineering strategies for IVD tissue repair/regeneration. In this Special Issue, we welcome original research including basic and translational research and reviews, but not clinical trials or case reports, covering subjects related, but not limited, to the following:
- Aging;
- Biomarkers of IVD disease;
- Cell signaling;
- Crosstalk;
- Extracellular matrix metabolism;
- Fibrosis;
- Immune response;
- In vitro, ex vivo, and in vivo models;
- Inflammation mediators;
- IVD repair/regeneration;
- Microbiome;
- Omics;
- Pathobiology of discogenic pain;
- Stem cells;
- Trauma.
Dr. Graciosa Teixeira
Guest Editor
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Keywords
- disc development
- healthy intervertebral disc
- IVD
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