The Mechanisms or Targets by Which the Microbiome Inhibits or Enhances Anti-inflammation or Tumor
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1548
Special Issue Editor
2. Division of Cancer Biology, Department of Medicine MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 10900, USA
Interests: gut mucosal immunology; epithelial barrier repair; inflammatory bowel diseases; colorectal cancer; intestinal epithelial and stem cell pathophysiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Background and Aims: Mounting evidence demonstrates that the gut microbiome is required for maintaining gut epithelial integrity, anti-inflammation or anti-tumor immunity, and systemic metabolism homeostasis. Shifts in gut microbial composition have been found to play a causal role in chronic mucosal inflammation and colon cancer. However, a lack of studies on the mechanisms or signaling pathways by which the microbiome acts on the host limits the development of microbiota treatments. Therefore, the Aim of this Special Issue is to promote basic and applied research that will identify the strains of gut beneficial or pathological bacteria and their metabolic products, with a particular emphasis on the mechanisms or targets by which the microbiota inhibits or enhances anti-inflammation or tumor.
Scope
- Gut microbiomeand epithelial integrity. In this part, the Special Issue is interested in by which signaling pathways the strains of gut commensal bacteria protect epithelial barriers from inflammation or pathogens.
- Gut microbiomeand anti-inflammation. In this part, the Special Issue is interested in the mechanics of the reduced Bifidobacterium and Lactobacillus in inflammatory bowel diseases (IBDs).
- Gut microbiome and anti-tumor. In this part, the Special Issue is interested in the signaling pathways by which the patients with a higher presence of Fusobacterium nucleatum or other validated onco-bacteria are prone to colon cancer.
- Gut microbiome and protective immune responses. It was recently shown that a subset of microbe-induced intestinal Th17 cells do not provoke intestinal inflammation. In this part, the Special Issue is interested in how specific gut microbiota promote host protective immune responses in cancer prevention.
- Gut microbiomeand immune tolerance. In this part, the Special Issue is interested in the effects of gut bacteria on the secretion of cytokines (e.g., IL-10), growth factor (e.g., TGF) and Treg cells that are able to suppress the inflammatory responses caused by microbiota-derived antigens in the gut.
- Gut microbiome and systemic metabolism homeostasis. In this part, the Special Issue is interested in how short-chain fatty acid production from microbiota affects anti-tumor immune functions, as well as examining how microbial bile acid metabolism modulates immune responses in colon tumors.
Dr. Xiaonan Han
Guest Editor
Manuscript Submission Information
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Keywords
- microbiome
- IBD
- colon cancer
- colitis-associated cancer
- Th17 cells
- cytokines
- immune tolerance
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