Inflammasome and Gut Immunity
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 251
Special Issue Editor
2. Division of Cancer Biology, Department of Medicine MetroHealth Medical Center (MHMC), Case Western Reserve University (CWRU), School of Medicine, Cleveland, OH 10900, USA
Interests: gut mucosal immunology; epithelial barrier repair; inflammatory bowel diseases; colorectal cancer; intestinal epithelial and stem cell pathophysiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammasomes are multiprotein complexes that consist of a sensor component, an adapter molecule, and an effector component. NLR‐associated inflammasomes (e.g., NLRP1, NLRP3, and NLRC4), absent in melanoma‐2 (AIM2)‐like receptor (ALR)‐associated inflammasomes, and the pyrin inflammasome are well known three inflammasomes. In gastrointestinak tract (GI), inflammasome can be activated by pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs). The activated inflammasomes can activate caspase-1 that cleaves pro IL-1β and pro IL-18 into mature IL-1β and IL-18. The active cytokines lead to a downstream inflammatory response and pyroptosis. Inflammasome are highly assembled in the organelles of intestinal epithelial cells and immune cells, by which they regulate the host defense against intestinal pathologic infection and inflammation. Defective inflammasome is known to play the critical role in the pathogenesis of Infectious Enteritis, Inflammatory Bowel Diseases (IBD), and Colorectal Cancer (CRC). However, there are several fields in GI inflammasome that are impending to be explored. 1. During GI homeostasis, by which types of cells the host mainly modulates the inflammasome to prevent intestinal microbiota dysbiosis; 2. During GI diseases, in what types of inflammasome plays a major role; 3. The pathogens prevented by inflammasome during GI diseases; 4. What baceria or ligands in GI tract can activate cellular inflammasmes; 5. How the inflammasome single-nucleotide polymorphisms (SNPs) impact GI infection, inflammation and cancer; 6. Druggable biomarker or potential medicine that target inflammasomes. This Special Issue includes, but not limited to above questions. The theme of this Special Issue aims to pursue the foundamental biology of GI inflammasomes and the applied infammasome translational medicine.
We look forward to your contributions.
Dr. Xiaonan Han
Guest Editor
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Keywords
- inflammasome
- gut immunity
- microbiota
- SNP
- IBD
- CRC
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