Celebrating Warburg's 100 Years: Cancer Metabolism and Beyond

Dear Colleagues,

This Special Issue of "Cells" celebrates Otto Warburg's ground-breaking investigations, which transformed our comprehension of cellular metabolism when they were conducted a century ago. Warburg's work has had a significant impact on cancer research, as well as revealing fundamental metabolic principles that apply to several biological processes. We examine the legacy of Warburg’s discoveries and their broader ramifications in this Special Issue. To highlight metabolic adaptations in healthy physiology and illness, we study the complex relationships between cellular metabolism, cancer biology, and other fields. The metabolic reprogramming of cancer cells and its consequences for carcinogenesis, progression, and treatment approaches are discussed by scientific experts. We also explore the role played by metabolism in various clinical states, such as metabolic syndromes, immunological dysregulation, and neurodegenerative diseases. We highlight novel metabolic imaging applications, demonstrating the potential of these methods to perform non-invasive illness diagnosis, prognosis, and therapy monitoring. In addition, we investigate the therapeutic targeting of metabolic pathways, including metabolic modulation in regenerative medicine and cancer-specific therapies. This Special Issue will promote interdisciplinary cooperation and increase our understanding of cellular metabolism by prioritizing original research articles and reviews. With the aim of pushing the boundaries of metabolic research in multiple fields, we invite academics to share their most recent discoveries, creative methods, and therapeutic applications. By contributing a paper to this Special Issue, authors can embrace the complexity of metabolism and enable game-changing research with far-reaching positive ramifications for human health.

The potential scope of this Special Issue includes, but is not limited to, the following topics:

• Metabolic reprogramming in cancer cells: mechanisms and therapeutic implications;
• The Warburg effect and its role in tumor initiation, progression, and metastasis;
• Beyond cancer: metabolic adaptations in neurodegenerative disorders;
• Metabolic syndromes and their connection to cellular metabolism;
• Immunometabolism: linking cellular metabolism to immune cell functions;
• Therapeutic targeting of metabolic pathways in cancer and other diseases;
• Metabolism and regenerative medicine: harnessing metabolic processes to enable tissue repair and regeneration;
• Metabolic biomarkers and their clinical applications in disease management;
• Insights from translational studies: applying metabolic knowledge to improve patient outcomes.

Prof. Dr. Rúben Fernandes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cancer metabolism
• metabolic reprogramming
• Warburg effect
• tumor microenvironment
• metabolic therapies
• metabolic biomarkers
• mitochondrial dysfunction