Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.9
5.1
Journals
Cells
Special Issues
Research Advances in Cellular and Molecular Biophysics
share announcement

Research Advances in Cellular and Molecular Biophysics

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3517

Special Issue Editor

Prof. Dr. Giuseppe Calamita

E-Mail Website
Guest Editor
Department of Biosciences, Biotechnologies and Environment, University of Bari “Aldo Moro”, 70125 Bari, Italy
Interests: cell physiology and pathophysiology; cellular and molecular biology; biophysics of the molecular transport properties of aquaporin membrane channels; aquaporins in health and disease; aquaporins as biomarkers and drug targets
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Research Advances in Cellular and Molecular Biophysics” will collect high-quality research articles and review articles in cutting-edge fields of Cellular and Molecular Biophysics. Since this Special Issue aims to illustrate, through selected works, frontier research in Cellular Biophysics, we encourage distinguished researchers from all over the world working in all related fields to contribute to this paper series. Relevant research topics include (but are not limited to) the following:

  • Cell mechanics (including membrane and cytoskeletal dynamics, plasticity);
  • Biophysics of membrane permeability;
  • Water and neutral solute channels;
  • Bioelectricity (including ion channels, exchangers, and pumps);
  • Intracellular and intercellular signaling dynamics;
  • Computational biophysics;
  • Emerging structural methods;
  • Electrophysiology;
  • Regulation of gene expression；
  • Post-translational regulation of proteins expression;
  • Protein dynamics;
  • Bioenergetics;
  • Cell signaling and receptors;
  • Other molecular details of how cellular components organize to generate and regulate specific activities.

We are pleased to invite you to contribute original articles, reviews, and communications, etc. All papers will be published on an ongoing basis with full open access. We look forward to receiving your interesting contributions.

Prof. Dr. Giuseppe Calamita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 2228 KiB  
Article
Electric Field Effects on Brain Activity: Implications for Epilepsy and Burst Suppression
by Evan D. Doubovikov, Natalya A. Serdyukova, Steven B. Greenberg, David A. Gascoigne, Mohammed M. Minhaj and Daniil P. Aksenov
Cells 2023, 12(18), 2229; https://doi.org/10.3390/cells12182229 - 7 Sep 2023
Viewed by 1158
Abstract
Electric fields are now considered a major mechanism of epileptiform activity. However, it is not clear if another electrophysiological phenomenon, burst suppression, utilizes the same mechanism for its bursting phase. Thus, the purpose of this study was to compare the role of ephaptic [...] Read more.
Electric fields are now considered a major mechanism of epileptiform activity. However, it is not clear if another electrophysiological phenomenon, burst suppression, utilizes the same mechanism for its bursting phase. Thus, the purpose of this study was to compare the role of ephaptic coupling—the recruitment of neighboring cells via electric fields—in generating bursts in epilepsy and burst suppression. We used local injections of the GABA-antagonist picrotoxin to elicit epileptic activity and a general anesthetic, sevoflurane, to elicit burst suppression in rabbits. Then, we applied an established computational model of pyramidal cells to simulate neuronal activity in a 3-dimensional grid, with an additional parameter to trigger a suppression phase based on extra-cellular calcium dynamics. We discovered that coupling via electric fields was sufficient to produce bursting in scenarios where inhibitory control of excitatory neurons was sufficiently low. Under anesthesia conditions, bursting occurs with lower neuronal recruitment in comparison to seizures. Our model predicts that due to the effect of electric fields, the magnitude of bursts during seizures should be roughly 2–3 times the magnitude of bursts that occur during burst suppression, which is consistent with our in vivo experimental results. The resulting difference in magnitude between bursts during anesthesia and epileptiform bursts reflects the strength of the electric field effect, which suggests that burst suppression and epilepsy share the same ephaptic coupling mechanism. Full article
(This article belongs to the Special Issue Research Advances in Cellular and Molecular Biophysics)
►▼ Show Figures

Graphical abstract

19 pages, 8531 KiB  
Article
Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak
by Xiaolan Zhang, Pengjia Bao, Qingbo Zheng, Min Chu, Chunnian Liang, Xian Guo, Xiaoyun Wu, Meilan He, Chengfang Pei and Ping Yan
Cells 2022, 11(24), 3985; https://doi.org/10.3390/cells11243985 - 9 Dec 2022
Viewed by 1729
Abstract
The interaction between the dermal papilla cells (DPCs) and epidermal hair matrix cells (HMCs) of hair follicles (HFs) is crucial for the growth and development of HFs, but the molecular mechanism is complex and remains unclear. MicroRNAs (miRNAs) are the key signaling molecules [...] Read more.
The interaction between the dermal papilla cells (DPCs) and epidermal hair matrix cells (HMCs) of hair follicles (HFs) is crucial for the growth and development of HFs, but the molecular mechanism is complex and remains unclear. MicroRNAs (miRNAs) are the key signaling molecules for cellular communication. In this study, the DPCs and HMCs of yak were isolated and cultured, and the differentially expressed mRNA and miRNA were characterized to analyze the molecular basis of the interaction between DPCs and HMCs during hair follicle (HF) development in yak. The mRNA differential expression and functional enrichment analysis revealed that there were significant differences between DPCs and HMCs, and they showed the molecular functional characteristics of dermal cells and epidermal cells, respectively. Multiple KEGG pathways related to HF development were enriched in the highly expressed genes in DPCs, while the pathways associated with microbiota and immunity were significantly enriched in the highly expressed genes in HMCs. By combining analysis with our previous 10× genomics single-cell transcriptome data, 39 marker genes of DPCs of yak were identified. A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. In conclusion, the large changes in yak DPCs and HMCs for both mRNA and miRNA expression were revealed, and numerous specifically expressed mRNAs and miRNAs in DPCs or HMCs were identified, which may contribute to the interaction and cellular communication between DPCs and HMCs during HF development in yak. Full article
(This article belongs to the Special Issue Research Advances in Cellular and Molecular Biophysics)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop