The Role of Inflammation in Atherosclerosis and Coronary Artery Disease

Dear Colleagues,

Atherosclerosis is the pathological basis of coronary artery disease, ischemic stroke, and peripheral arterial disease. Despite optimal treatment with drugs to alleviate hyperlipidemia and hypertension and prevent thrombotic complications, this disease continues to be the leading causes of morbidity and mortality worldwide.  Thus, there is a medical need for understanding the pathogenesis of atherosclerosis and finding new targets to combat the disease.

Inflammation is a key process that drives the initiation, progression, and even rupture of atherosclerotic plaques. Dyslipidemia, hypertension, obesity, and type 2 diabetes have been identified as major risk factors for atherosclerosis.  These conditions are closely linked and are often concomitant with inflammation or exacerbate pre-existing inflammation.  Recent evidence links the above conditions to the activation of pro-inflammatory molecules accelerating atherosclerosis. There is also evidence on the role of genetic factors in the production of pro-inflammatory molecules during atherogenesis. Deciphering the crosstalk between major risk factors and inflammation in atherosclerosis should lead to a better understanding of the pathophysiological mechanisms and would help identify new targets and develop better therapeutical strategy for treatment.

In this Special Issue, we will consider both original and review articles that centered on molecular and genetic aspects of inflammation in atherosclerosis. We look forward to receiving your contributions.

Prof. Dr. Weibin Shi
Prof. Dr. Voahanginirina Randriamboavonjy 
Guest Editors

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