Advances in Intestinal Epithelial Plasticity and Regeneration

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 778

Special Issue Editor

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, Louisiana Cancer Research Center, New Orleans, LA 70112, USA
Interests: intestine stem cells; tissue damage; homeostasis and regeneration; epithelial tumors and cell polarity
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Special Issue Information

Dear Colleagues,

The intestinal epithelium is a dynamic and highly regenerative tissue that plays a pivotal role in nutrient digestion and absorption, hormone secretion, and the response to various challenges such as injury, infection, and inflammation. It has a remarkable capacity for self-renewal under normal homeostatic conditions and regeneration in response to tissue damage. It is crucial that we gain insights into the mechanisms that govern intestinal epithelial self-renewal, plasticity and regeneration in order to enhance our understanding of gastrointestinal health and disease.

This Special Issue is dedicated to exploring the latest advancements in the field of intestinal epithelial plasticity and regeneration. We welcome contributions that focus on, but are not limited to, the following topics:

  1. Molecular mechanisms that regulate the function and differentiation of intestinal stem cells (ISCs);
  2. Cellular plasticity within the intestinal epithelium during homeostasis, tissue damage, and disease;
  3. Interactions between the intestinal epithelium and the microbiota in health and disease;
  4. Therapeutic strategies aimed at promoting intestinal regeneration and repair.

We look forward to your contributions.

Dr. Aiguo Tian
Guest Editor

Manuscript Submission Information

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Keywords

  • intestinal epithelium
  • epithelial plasticity
  • stem cells
  • tissue repair
  • self-renewal
  • regeneration

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Published Papers (1 paper)

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Review

18 pages, 1180 KiB  
Review
Regulation of the Intestinal Stem Cell Pool and Proliferation in Drosophila
by Simona Trubin, Dhruv B. Patel and Aiguo Tian
Cells 2024, 13(22), 1856; https://doi.org/10.3390/cells13221856 - 8 Nov 2024
Viewed by 570
Abstract
Understanding the regulation of somatic stem cells, both during homeostasis and in response to environmental challenges like injury, infection, chemical exposure, and nutritional changes, is critical because their dysregulation can result in tissue degeneration or tumorigenesis. The use of models such as the [...] Read more.
Understanding the regulation of somatic stem cells, both during homeostasis and in response to environmental challenges like injury, infection, chemical exposure, and nutritional changes, is critical because their dysregulation can result in tissue degeneration or tumorigenesis. The use of models such as the Drosophila and mammalian adult intestines offers valuable insights into tissue homeostasis and regeneration, advancing our knowledge of stem cell biology and cancer development. This review highlights significant findings from recent studies, unveiling the molecular mechanisms that govern self-renewal, proliferation, differentiation, and regeneration of intestinal stem cells (ISCs). These insights not only enhance our understanding of normal tissue maintenance but also provide critical perspectives on how ISC dysfunction can lead to pathological conditions such as colorectal cancer (CRC). Full article
(This article belongs to the Special Issue Advances in Intestinal Epithelial Plasticity and Regeneration)
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