Dysregulation of Calcium Signalling in Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (15 March 2021) | Viewed by 50103
Special Issue Editor
Interests: calcium; mitochondria; Mitochondrial Ca2+ Uniporter (MCU) complex; ER-mitochondria contacts; Mitochondria-Associated Membranes (MAMs); Ca2+-mediated apoptosis
Special Issue Information
Dear Colleagues,
Calcium is the major second messenger inside the cell and acts as the most prominent signaler in a plethora of biological processes. Its homeostasis is preserved by a sophisticated system of channels, pumps, and exchangers, which ensure a low cytoplasmic Ca2+ concentration at resting conditions and prompt Ca2+ elevation upon specific stimulations.
Importantly, Ca2+ regulation is not symmetrical throughout the cell, and different subcellular districts, such as endoplasmic reticulum, mitochondria or lysosomes, are equipped with peculiar Ca2+ regulating machinery. In the last years, fantastic advances have been made in the molecular characterization of novel Ca2+ players or in the identification of unexpected Ca2+ signaling routes. It is now clear that Ca2+ alterations in a specific organelle or mutations in Ca2+ transporters and/or Ca2+-related pathways have a huge impact on the activities and functionalities of the entire cell. Therefore, it is not surprising that Ca2+ dyshomeostasis or deregulation of a single Ca2+-permeable channel have been associated with multiple pathological scenarios, including cardiovascular and neurological defects, metabolic disorders, muscular diseases, and cancers.
This Special Issue of Cells is dedicated to the role of imbalanced Ca2+ signaling in disease. Contributions in the form of original experimental articles, up-to-date reviews, or short communications are welcome. We hope that this collection of papers may help the readers to point out the contribution and the mechanistic role of Ca2+ in different pathological contexts.
Dr. Saverio Marchi
Guest Editor
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Keywords
- Calcium
- intracellular organelles
- plasma membrane
- store-operated Ca2+ entry (SOCE)
- inositol 1,4,5 trisphosphate receptors (IP3Rs)
- sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)
- mitochondrial calcium uniporter (MCU)
- sodium/calcium exchanger
- ORAI and STIM proteins
- mitochondrial permeability transition pore (mPTP)
- TRP channels
- cardiovascular diseases
- neurodegenerative diseases
- metabolic diseases
- ageing
- muscular diseases
- cancer
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