Cellular and Molecular Biology of Melatonin

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 6509

Special Issue Editors


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Guest Editor
Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan
Interests: stem cell biology (iPS cells, mesenchymal stem cells, dental-pulp-derived stem cells) and regenerative medicine including tissue engineering; wound healing; cell biology for melatonin; cell biology for leptin; tooth development; cell biology of grapefruit seed extract; cell biology of candida species; cell biology of oral cancer; photodynamic diagnosis and treatment; photoimmunotherapy
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Assistant Guest Editor
Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan
Interests: stem cell biology (iPS cells, mesenchymal stem cells, dental-pulp-derived stem cells) and regenerative medicine including tissue engineering; wound healing; cell biology for melatonin; cell biology for leptin; tooth development; cell biology of oral cancer; photodynamic diagnosis and treatment; photoimmunotherapy; extracellular vesicles; SARS-CoV-2

Special Issue Information

Dear Colleagues,

Melatonin, a hormone primarily synthesized and secreted by the pineal gland at night, has a variety of physiological actions, including not only the control of circadian rhythms, but also the regulation of body temperature, activation of the immune system, anti-tumor activity, and hormone secretion, influencing sexual development and the reproductive cycle in seasonally breeding animals. This accumulating evidence concerning the action of melatonin also clearly demonstrates the potential of this hormone as a therapeutic target.

This Special Issue of Cells will provide a platform to discuss the various aspects of melatonin and its receptors. We invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Cellular and Molecular Biology of Melatonin”. Expert articles describing the potential use of melatonin as a therapeutic for a variety of diseases are highly welcome. Relevant topics include, but are not limited to:

  • Biosynthesis;
  • Signal transduction;
  • Circadian rhythm;
  • Sleep–wake cycle;
  • Antioxidant;
  • Radioprotection;
  • Immune system;
  • Sleep disorder;
  • Dementia;
  • Psychiatry;
  • Cancer;
  • Therapeutics;
  • Pharmacology;
  • Dietary supplement;
  • Plants;
  • Microorganisms.

Prof. Dr. Kazuhito Satomura
Dr. Reiko Tokuyama-Toda
Guest Editors

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Keywords

  • melatonin
  • melatonin receptor
  • biosynthesis
  • circadian rhythm
  • antioxidant
  • immune system
  • pharmacology
  • sleep disorder
  • dementia
  • cancer
  • radioprotection

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Published Papers (2 papers)

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Research

18 pages, 4427 KiB  
Article
The Preventive Effect of Melatonin on Radiation-Induced Oral Mucositis
by Reiko Tokuyama-Toda, Hirochika Umeki, Mitsuru Okubo, Chika Terada-Ito, Toshio Yudo, Shinji Ide, Susumu Tadokoro, Masashi Shimozuma and Kazuhito Satomura
Cells 2023, 12(17), 2178; https://doi.org/10.3390/cells12172178 - 30 Aug 2023
Cited by 2 | Viewed by 2028
Abstract
Melatonin exerts various physiological effects through melatonin receptors and their ability to scavenge free radicals. Radiotherapy is a common treatment for head and neck tumors, but stomatitis, a side effect affecting irradiated oral mucosa, can impact treatment outcomes. This study investigated the preventive [...] Read more.
Melatonin exerts various physiological effects through melatonin receptors and their ability to scavenge free radicals. Radiotherapy is a common treatment for head and neck tumors, but stomatitis, a side effect affecting irradiated oral mucosa, can impact treatment outcomes. This study investigated the preventive effect of melatonin, a potent free radical scavenger, on radiation-induced oral mucositis. Mice were irradiated with 15 Gy of X-ray radiation to the head and neck, and the oral mucosa was histologically compared between a melatonin-administered group and a control group. The results showed that radiation-induced oral mucositis was suppressed in mice administered melatonin before and after irradiation. It was suggested that the mechanism involved the inhibition of apoptosis and the inhibition of DNA damage. From these findings, we confirmed that melatonin has a protective effect against radiation-induced oral mucositis. Full article
(This article belongs to the Special Issue Cellular and Molecular Biology of Melatonin)
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16 pages, 3083 KiB  
Article
Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
by Beatriz I. Fernandez-Gil, Andrea Otamendi-Lopez, Alexandra Bechtle, Carla A. Vazquez-Ramos, Neda Qosja, Paola Suarez-Meade, Rachel Sarabia-Estrada, Mark E. Jentoft, Hugo Guerrero-Cázares, Germaine Escames, Paula Schiapparelli and Alfredo Quiñones-Hinojosa
Cells 2022, 11(21), 3467; https://doi.org/10.3390/cells11213467 - 2 Nov 2022
Cited by 3 | Viewed by 3622
Abstract
Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM [...] Read more.
Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM tumor initiating cells. GBM tumor initiating cells were treated at different times with melatonin (1.5 and 3.0 mM). We analyzed melatonin’s functional effects on GBM proliferation, cell cycle, viability, stemness, and chemo-radiosensitivity. We then assessed the effects of melatonin on GBM metabolism by analyzing the mitochondrial and glycolytic parameters. We also measured the intracellular and extracellular pH. Finally, we tested the effects of melatonin on a mouse subcutaneous xenograft model. We found that melatonin downregulated LDHA and MCT4, decreasing lactate production and inducing a decrease in intracellular pH that was associated with an increase in ROS and ATP depletion. These changes blocked cell cycle progression and induced cellular death and we observed similar results in vivo. Melatonin’s cytotoxic effects on GBM were due, at least in part, to intracellular pH modulation, which has emerged as a newly identified mechanism, providing new insights into the oncostatic effect of melatonin on GBM. Full article
(This article belongs to the Special Issue Cellular and Molecular Biology of Melatonin)
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