Cellular and Molecular Mechanisms of Atherosclerosis
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Cells of the Cardiovascular System".
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Interests: ahterosclerosis; inflammation; NF-kB; nulcear receptor; endocrine disrupting chemicals
Topical Collection Information
Dear Colleagues,
Atherosclerotic cardiovascular disease (CVD) is still the leading cause of mortality and morbidity worldwide despite advanced diagnosis and treatments. Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory molecules in the subendothelium of the artery, leading to restricted blood flow and ultimately myocardial infarction and stroke. Atherosclerosis is a complex chronic disease involving the interaction of genetic and environmental factors over multiple years. A multitude of treatments have been developed to halt or reverse the progression of this disease, including lifestyle changes, interventional procedures such as angioplasty and stent placement, and the prescription of medications to lower blood cholesterol levels, prevent clot formation, and reduce blood pressure. While these treatments have undoubtedly improved outcomes, there is more room for improvement. As a result, new classes of therapeutics are being developed to address the shortcomings of existing treatments. At the same time, inquiries into the basic biological mechanisms of atherosclerosis continue at a rapid pace.
In this Special Issue of Cells, we invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Atherosclerosis”. Expert articles describing the mechanistic, functional, cellular, biochemical, or general aspects of atherosclerosis are highly welcome.
Dr. Changcheng Zhou
Dr. Hong Chen
Guest Editors
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Keywords
- signaling pathways
- macrophage function
- endothelial cell function and endothelial–mesenchymal transition in atherosclerosis
- smooth muscle cell function and smooth muscle transdifferentiation in atherosclerosis
- lipid homeostasis
- mechanotransduction
- system biology
- environmental exposure
- novel biomarkers
- microbiota metabolism
- in vitro and in vivo models
- atherosclerosis calcification
- small noncoding rnas and long noncoding rnas
- covid-19
- bioimaging
- translational medicine
- sex differences in atherosclerosis
- new therapeutics