Signaling and Cell Migration in Cerebral Cortex Development
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 5881
Special Issue Editor
Interests: neurogenesis; loco motion; multipolar movement; synapse; neuronal migration; brain evolution; cerebral neocortex; Rp58; lens; transcription factors; MIP; Ap2; sub plate
Special Issue Information
Dear Colleagues,
The six-layered structure of the cerebral cortex consists of neurons born in the ventricular zone, arranged in orderly layers according to the time of their birth date. An accurate understanding of the mechanisms of neuronal migration is fundamental to understanding the development of the neocortex and the pathogenesis of developmental neurological disorders. New neurons are generated in the ventricular zone in the developing cerebrum and then migrate to their final destination to function. Abnormalities in the migration of neurons during development cause abnormalities in the structure and function of the neocortex, leading to a variety of disorders such as epilepsy and developmental disorders.
During migration, neurons sense various extracellular environmental signals, including biochemical and mechanical cues, and behave in response to these signals. Gene networks and signaling pathways involved in neuronal migration have been identified using various methods. More recently, it has been shown that the earliest-born subplate neurons in the subplate layer facilitate migration mode conversion in radial neuronal migration.
This Special Issue aims to gain a better understanding of the signaling systems that control the developmental process of the cortex and the mechanisms that regulate cell migration.
Dr. Chiaki Ohtaka-Maruyama
Guest Editor
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Keywords
- cerebral cortex
- neuronal migration
- subplate
- cell–cell interaction
- extracellular environment development
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