Bone Regeneration and Repair: Replacing What Has Been Lost through Science

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 872

Special Issue Editor


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Guest Editor
1. Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università Degli Studi di Milano, 20122 Milan, Italy
2. IRCCS Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico, 20133 Milano, Italy
Interests: histology; bone; muscle; animal models; staining techniques; microscopy; endodotic microbiology; teeth diseases; teeth histology; bone regeneration; bone substitutes

Special Issue Information

Dear Colleagues,

Bone tissue serves as fundamental support for the human body and is as vital as breathing or the heartbeat. Being a biological structure, it can face various situations that may hinder its proper functioning, resulting from traumatic, surgical or pathological events. Over the years, science has continuously sought ways to regenerate, heal or restore damaged bone tissue due to its importance. A functional skeletal system not only fulfills physiological functions, but also impacts psychological well-being, making topics related to bone regeneration an enduring focus of research.

This Special Issue aims to present the current state-of-the-art and innovative techniques that may one day lead to successful bone tissue regeneration. It will cover various forms of bone regeneration, including those in orthopedics and dentistry. The issue will showcase innovative materials, novel applications of existing products and cutting-edge technologies such as additive manufacturing for scaffold creation. Along these topics, significance of the biological processes involved in bone regeneration will not be overlooked, as they play a vital role in understanding the mechanisms and exploring potential applications. The quest for advancements in bone regeneration will continue to be a prominent area of research and innovation in the coming years, paving the way for significant medical breakthroughs.

Dr. Paolo Savadori
Guest Editor

Manuscript Submission Information

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Keywords

  • bone
  • regenerative
  • bone defect
  • tissue engineering
  • histology
  • animal models
  • bone biology
  • 3D printing
  • biomaterials
  • bone surgery

Published Papers (1 paper)

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Review

23 pages, 7798 KiB  
Review
Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions
by Marcel G. Brown, Davis J. Brady, Kelsey M. Healy, Kaitlin A. Henry, Ayobami S. Ogunsola and Xue Ma
Cells 2024, 13(12), 1045; https://doi.org/10.3390/cells13121045 - 17 Jun 2024
Viewed by 598
Abstract
Bone/fracture healing is a complex process with different steps and four basic tissue layers being affected: cortical bone, periosteum, fascial tissue surrounding the fracture, and bone marrow. Stem cells and their derivatives, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, [...] Read more.
Bone/fracture healing is a complex process with different steps and four basic tissue layers being affected: cortical bone, periosteum, fascial tissue surrounding the fracture, and bone marrow. Stem cells and their derivatives, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells, skeletal stem cells, and multipotent stem cells, can function to artificially introduce highly regenerative cells into decrepit biological tissues and augment the healing process at the tissue level. Stem cells are molecularly and functionally indistinguishable from standard human tissues. The widespread appeal of stem cell therapy lies in its potential benefits as a therapeutic technology that, if harnessed, can be applied in clinical settings. This review aims to establish the molecular pathophysiology of bone healing and the current stem cell interventions that disrupt or augment the bone healing process and, finally, considers the future direction/therapeutic options related to stem cells and bone healing. Full article
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