Protein Kinases in Cancer Stem Cells, Carcinogenesis, Senescence and Cancer Treatment

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 1903

Special Issue Editor


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Guest Editor
Proteomics Center, Institute of Biochemistry, Vilnius University Life Sciences Center, Vilnius University, 10223 Vilnius, Lithuania
Interests: cancerogenesis; cancer cells drug resistance; cell signaling in cancer and normal cells; protein kinases in cancerogenesis; proteomics; confocal microscopy
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Special Issue Information

Dear Colleagues,

This Special Issue aims to bring together cutting-edge research in the field of protein kinases and present advancements in their role in cancer stem cells (CSCs), carcinogenesis, and cancer treatment.

Cancer stem cells have been identified as a critical component in the process of carcinogenesis and are believed to contribute to tumor initiation, progression, and therapy resistance. Despite their significance, the precise mechanisms underlying the involvement of protein kinase networks in the regulation of cancer stem cells still await detailed elucidation.

As part of this Special Issue, we are particularly encouraging your contributions that shed light on the role of protein kinase networks in cancer cell senescence, as this emerging area holds great promise as a novel therapeutic strategy. Understanding the mechanisms of cancer cell senescence and its connection to protein kinase signaling pathways is vital for developing novel therapeutic strategies.

By elucidating the dysregulation of protein kinases in carcinogenesis and exploring their potential as therapeutic targets, we can pave the way for innovative approaches to cancer therapy and personalized medicine.

We invite you to submit a manuscript that addresses one or more of the following topics:

  • Protein kinase signaling pathways in cancer stem cells;
  • Dysregulation of protein kinases in carcinogenesis;
  • Novel therapeutic strategies targeting protein kinases for cancer therapy and personalized medicine;
  • Protein kinases and therapy resistance in cancer;
  • Targeting cancer cell senescence via protein kinase networks.

Your valuable research insights and findings in any of these areas would greatly enrich the scientific knowledge and advancements in the field. We encourage you to share your expertise and contribute to this Special Issue, as your contributions can play a significant role in shaping the future of cancer research and treatment.

Dr. Mindaugas Valius
Guest Editor

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Keywords

  • protein kinase
  • cancer stem cell
  • senescence

Published Papers (1 paper)

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Review

15 pages, 2264 KiB  
Review
Hippo Signaling at the Hallmarks of Cancer and Drug Resistance
by Ramesh Kumar and Wanjin Hong
Cells 2024, 13(7), 564; https://doi.org/10.3390/cells13070564 - 22 Mar 2024
Cited by 2 | Viewed by 1657
Abstract
Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by inhibiting proliferation and promoting apoptosis. Large tumor suppressors 1 and 2 (LATS1/2) directly phosphorylate the Yki orthologs YAP (yes-associated protein) [...] Read more.
Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by inhibiting proliferation and promoting apoptosis. Large tumor suppressors 1 and 2 (LATS1/2) directly phosphorylate the Yki orthologs YAP (yes-associated protein) and its paralog TAZ (also known as WW domain-containing transcription regulator 1 [WWTR1]), thereby inhibiting their nuclear localization and pairing with transcriptional coactivators TEAD1-4. Earnest efforts from many research laboratories have established the role of mis-regulated Hippo signaling in tumorigenesis, epithelial mesenchymal transition (EMT), oncogenic stemness, and, more recently, development of drug resistances. Hippo signaling components at the heart of oncogenic adaptations fuel the development of drug resistance in many cancers for targeted therapies including KRAS and EGFR mutants. The first U.S. food and drug administration (US FDA) approval of the imatinib tyrosine kinase inhibitor in 2001 paved the way for nearly 100 small-molecule anti-cancer drugs approved by the US FDA and the national medical products administration (NMPA). However, the low response rate and development of drug resistance have posed a major hurdle to improving the progression-free survival (PFS) and overall survival (OS) of cancer patients. Accumulating evidence has enabled scientists and clinicians to strategize the therapeutic approaches of targeting cancer cells and to navigate the development of drug resistance through the continuous monitoring of tumor evolution and oncogenic adaptations. In this review, we highlight the emerging aspects of Hippo signaling in cross-talk with other oncogenic drivers and how this information can be translated into combination therapy to target a broad range of aggressive tumors and the development of drug resistance. Full article
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