Brain Injury in Patients with Cardiac and Pulmonary Diseases

Dear Colleagues,

In patients with lung diseases, a complex relationship between the brain and the lungs has been demonstrated by experimental and clinical studies over the past few decades. Even though acute brain injury is one of the most common complications in acute respiratory distress syndrome (ARDS) patients, the intricacy of the underlying pathophysiology of the observed crosstalk makes it difficult to fully understand. The brain of ARDS patients becomes extremely susceptible to developing secondary lung-mediated acute brain injury due to several pathophysiological factors, including hypoxemia, neurological adverse events of lung protective ventilation, hypotension, disruption of the blood–brain barrier, and neuroinflammation. A protective ventilator technique could limit or even stop the flow of further inflammatory mediators into the body, preserving brain homeostasis. Similar to patients with lung diseases, those with cardiovascular derangements are highly susceptible to acute brain injury. This Special Issue will include articles that investigate and review the close interaction between the heart and the brain and highlight the neurological complications of patients with cardiac diseases. In addition, this Special Issue highlights brain injury and cerebrovascular complications of patients with mechanical circulatory support devices.

The aim of this Special Issue is to publish papers on brain–lung and brain–heart interactions. We look forward to receiving review articles, brief reports, original research, preclinical experimental studies, narrative reviews, systematic reviews and meta-analyses.

Dr. Sung-Min Cho
Dr. Denise Battaglini
Guest Editors

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