Innate Cellular Immunity in Xenotransplantation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 1975
Special Issue Editor
Special Issue Information
Dear Colleagues,
Xenotransplantation, cross-species transplantation, is a promising solution to human organ shortage. Recent advancements in the genetic engineering of pigs to improve pig–human compatibility has brought us closer to achieving successful xenotransplantation. Human antibody-mediated hyperacute rejection can be effectively prevented by eliminating xenoantigens on porcine xenograft. However, immune-cell-mediated xenograft rejection remains a barrier for the application of xenotransplantation in the clinic. Innate immune cells including natural killer cells, macrophages, dendritic cells, and neutrophils contribute to xenograft destruction. To achieve a long-term porcine xenograft survival in humans, inhibiting the activation of human innate immune cell is crucial.
This Special Issue seeks to publish original research and review articles on the mechanisms of human innate immune cell activation to porcine cell stimulation, novel strategies to promote local innate immune tolerance via the genetic engineering of pigs (through the addition of human inhibitory molecules and “markers of self”, and the elimination of porcine activation molecules), and the current status of immunosuppressive agents on innate immune response in xenotransplantation.
Dr. Ping Li
Guest Editor
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Keywords
- innate immunity
- natural killer cells
- microphages
- dendritic cells
- neutrophils
- xenotransplantation
- immune rejection
- immune tolerance
- xenograft
- genetic engineering
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