The Role of Mitochondria in Cell Development and Regeneration

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2372

Special Issue Editors


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Guest Editor
Karolinska Institutet, Stockholm, Sweden
Interests: the impact of cancer treatment on fertility potential; the prevention of infertility through fertility preservation strategies; the impact of variables and interventions in the development of infertility; the ART treatment of infertility in both men and women; the psychological aspects of infertility after cancer; ethics in health care provision; an evaluation of the safety and efficacy of fertility preservation based on surgical methods ; the performance of ART; cancer during pregnancy
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Guest Editor Assistant
Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
Interests: mechanisms of alkylating chemotherapeutic treatment induced female infertility; potential pharmaceutical treatment against alkylating chemotherapeutic treatment’s insults on female fertility; ovarian aging and mitochondria’s function in primordial follicles

Special Issue Information

Dear Colleagues,

Mitochondria, i.e., bi-membrane structured organelles, are crucial in multifaceted cellular processes in eukaryotic cells (including energy production, calcium homeostasis maintenance, signaling pathways, programmed cell death, metabolism, organic compounds biosynthesis, etc.). Mitochondrial dynamics (fusion and fission), mitochondrial distribution, and mtDNA copy number alterations are associated with the regulation of various cellular activities, and vice versa, but those cellular activities could regulate mitochondria-related changes. In the context of a whole cell, mitochondria interact with the nucleus and other organelles such as the endoplasmic reticulum, thus influencing multiple cellular activities. In the circumstance of an organ or system, signals from other cells through, e.g., through cell–cell communications, could also regulate cellular activities. Mitochondria in different cell types of different organs or systems (e.g., neuro system, immune system, ovary, and embryonic development) vary in their quantities, mtDNA copy numbers, distribution patterns, as well as their morphological characteristics and powers in regulating above-mentioned multifaceted cellular processes. Under all those processes, cells develop (physiological processes); meanwhile, cells react and adapt to diverse internal and external cellular stresses (pathological processes). However, the role of mitochondria in cell development has only partially been revealed. In this Special Issue, we welcome all types of manuscripts in both basic and clinical researches aimed at elucidating mitochondrial functions in cell development.

Dr. Kenny Rodriguez-Wallberg
Guest Editor

Dr. Xia Hao
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • mitochondria
  • fusion and fission
  • mtDNA
  • programmed cell death
  • cell development
  • mitochondria-ER contact
  • organelle

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Published Papers (1 paper)

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Research

17 pages, 1722 KB  
Article
Mitochondrial Reactive Oxygen Species Production in Vascular Dementia Following Experimental Diabetes
by Ed Wilson Santos, Subika Khatoon, Yun-Min Zheng and Yong-Xiao Wang
Cells 2025, 14(16), 1260; https://doi.org/10.3390/cells14161260 - 15 Aug 2025
Viewed by 1533
Abstract
Type 1 diabetes (T1D) is a serious disease which affects millions of people worldwide and is a major factor for vascular contributions to cognitive impairment and dementia (VCID). In this study, we first characterized cognitive and memory impairments, then evaluated their underlying molecular [...] Read more.
Type 1 diabetes (T1D) is a serious disease which affects millions of people worldwide and is a major factor for vascular contributions to cognitive impairment and dementia (VCID). In this study, we first characterized cognitive and memory impairments, then evaluated their underlying molecular mechanisms, and finally determined sex-dependent effects in male and female mice with streptozotocin (STZ)-induced T1D. Our findings indicated that significant cognitive impairment, memory loss, and vascular dementia occurred in male and female T1D mice. Cerebral artery (CA) blood flow was greatly reduced in the various brain regions tested. ROS generation in isolated cells, mitochondria, and mitochondrial complex III from CA smooth muscle cells (CASMCs) were all increased in T1D. DNA damage and Tau phosphorylation in CASMCs were largely increased. Linear regression analysis revealed that T1D-induced increased blood glucose was highly correlated with increased ROS production and increased VCID. Taken together, we conclude that T1D causes increased mitochondrial complex III ROS production, DNA damage, and Chk2 phosphorylation in CASMC, thereby leading to vascular dementia in both male and female mice; our results further demonstrate that mitochondrial complex III ROS-mediated DNA damage is more significant in male than female mice, which contributes to more serious vascular dementia in the former than the latter. Full article
(This article belongs to the Special Issue The Role of Mitochondria in Cell Development and Regeneration)
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