MicroRNAs in Cancer: Biomarkers, Functions and Therapies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 13668
Special Issue Editor
Interests: RNA-binding proteins; miRNAs; mRNA turnover; translation; post-transcriptional gene regulation and cancer
Special Issue Information
Dear Colleagues,
Regulation of gene expression is a multi-step biological process, mainly controlled at the co- or post-transcriptional levels in eukaryotes. A dysfunctional post-transcriptional gene regulation leads to aberrant expression of oncoproteins to promote cancers. MicroRNAs are small non-coding RNAs that control gene expression by targeting mRNAs at the post-transcriptional level. Cancer cells encompass thousands of miRNAs that are either amplified or downregulated, which become oncomiRs or tumor suppressors, respectively. One of the significant steps in the behavior of miRNAs is the activation or the repression of their target genes. Thus, miRNAs can serve as biomarkers, regulating gene expression and being used as therapeutic molecules to target oncoproteins in cancers.
In this Special Issue of Cells, we collect original discoveries and reviews related to miRNAs as potential biomarkers in cancers, function as oncomiRs or tumor suppressors, and as therapeutic targets for cancers. Studies looking at the functional role of miRNAs in mRNA turnover and translational control will be taken into consideration. Specific topics in this Special Issue include the cancer relevance of regulation of miRNA expression, miRNAs as predictive biomarkers in cancer tissues and cells, amiRNA-mediated post-transcriptional changes at the functional level, which modulate transcriptomics and proteomics, and miRNAs as cancer therapeutics.
This Special Issue should serve as an opportunity for molecular and cancer biologists to share their experimental data and theories to help understand the novel role of miRNAs in cancers for future innovative discoveries.
We look forward to your contributions to this Special Issue.
Dr. Viswanathan Palanisamy
Guest Editor
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Keywords
- miRNAs
- biomarkers
- oncomiRs
- tumor suppressors
- miRNA therapeutics
- mRNA turnover
- mRNA translational control
- post-transcriptional gene regulation
- cancer
- transcriptional activation of miRNAs in cancer
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