Remyelination: From Basic Science to Therapies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 967
Special Issue Editor
Interests: oligodendroglia differentiation; remyelination; multiple sclerosis; neurodegeneration; intracellular traffic; yeast
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Myelin sheath damage can occur because of autoimmune attacks, inflammatory processes, and viral infections, invariably leading to neurodegeneration. Remyelination is a spontaneous process that can restore cognitive and functional deficits resulting from myelin sheath injury. Myelin regeneration is also neuroprotective; therefore, identifying regenerative therapies will improve patient quality of life by restoring lost functions and reducing disease progression. Despite significant advances in identifying the factors that trigger myelin damage and the mechanisms through which myelin sheath restoration occurs, in both healthy and pathological conditions, effective disease-modifying therapies that halt or reverse myelin degeneration remain an urgent need.
Undoubtedly, the complexity of the pathogenic mechanisms behind demyelination in Multiple Sclerosis (MS), Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and autism spectrum disorders (ASD) makes phenotypic screening and regenerative therapy testing challenging. To decipher this complex scenario, it is essential to consider that remyelination failure is not only due to defects in oligodendrocyte precursor differentiation but is also strongly influenced by alterations in the surrounding environment. Inflammation and aberrant crosstalk between neural and glial cells are among the causes leading to the disruption of homeostatic mechanisms that regulate regenerative processes in the Central Nervous System (CNS). Dysregulation of immunological surveillance of the CNS, exemplified by aberrant microglial activation, and disruption of myelin sheath integrity represent key events in the early stages of various neurodegenerative conditions.
In this Special Issue, we aim to collect manuscripts that shed new light on the cellular events underlying demyelination in MS, PD, AD, and ASD, as well as studies that review the use iPSC-derived cells, organoids, artificial intelligence, and ultrasound technologies to provide new perspectives on the therapeutic potential of regenerative therapies.
Dr. Antonella Ragnini-Wilson
Guest Editor
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Keywords
- myelin disease
- neurodegeneration
- CNS therapy
- stem cells
- regenerative therapies
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