Cellular Signaling in Regeneration of Nervous System
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1749
Special Issue Editors
Interests: oligodendroglia differentiation; remyelination; multiple sclerosis; neurodegeneration; intracellular traffic; yeast
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
To date, several therapeutic agents aiming to stimulate brain tissue regeneration have been identified, but their translation to humans has encountered more difficulty than originally thought (Allanach et al., 2021).
These pharmacological approaches can reduce neurodegenerative processes or overcome disease disability in cells and animals, but we are still awaiting regenerative and neuroprotective strategies to be approved for human use for neurodegenerative pathologies such as multiple sclerosis, Parkinson and Alzheimer disease. For the case of multiple sclerosis, opicinumab (anti-LINGO-1) and high-dose biotin (MD1003) initially showed promise for their regenerative activity, but they finally met pivotal clinical trial end points (Amin et al., 2022). Cumulating evidence suggests that the concept of “one-disease-one-target” can be challenged as neurodegeneration involves multiple cell types, and combinatorial approaches might be necessary (Cole et al., 2017, Silva et al., 2022). Regeneration of the nervous system will be our next mission. Clearly, to reach this point, much has to be known about the signals leading to the regenerative process in neurons, astrocytes, microglia and oligodendrocyte. Indeed, the drug selected for their regenerative activity in a large repurposing screen will be a valuable tool that can be used to elucidate as-yet-unknown pathways in disease models. Clearly, a further understanding of the fundamental principles regulating the renewal and regeneration of human brain tissues is fundamental for these drugs to further develop and receive clinical attention. This Special Issue calls for research and review articles on topics related to the study of regenerative processes in the central nervous system.
Dr. Antonella Ragnini-Wilson
Dr. Songlin Zhou
Guest Editors
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Keywords
- nerve regeneration
- miRNA
- epigenetics
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