Ras Proteins and Their Regulators in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 295
Special Issue Editor
Special Issue Information
Dear Colleagues,
In this Special Issue, we will focus on the regulation of Ras and Ras-like GTPase proteins in human disease, including the role of Ras and Rab proteins in cancer and neurodegeneration. While much work has focused on the regulation of Ras and Ras-like small GTPases (Ras proteins) by GEFs and GAPs, other interacting or regulatory factors are critical contributors to the cellular outcomes of signaling through Ras proteins. For example, depending upon the precise Ras family member, activated Ras proteins can recruit specific binding partners, such as sorting adaptors, tethering factors, kinases, phosphatases, and motor proteins. These complexes can influence not only cell signaling, but also other critical intracellular events that may include vesicle formation, transport, and tethering.
The purpose of this Special Issue is to focus on research progress involved in the regulation of Ras proteins by adaptors or modulatory factors that may be present in a complex with the Ras protein, or participate in the attachment or tethering of the Ras protein to intracellular organelles or multi-subunit complexes, including those undergoing trafficking inside cells.
Advances in our understanding of the mechanisms underlying the regulation of Ras proteins will facilitate the development of new insights and novel therapeutic targeting approaches for human disease. Consequently, we invite the community to submit either original articles or reviews covering the above mentioned field.
We look forward to your contributions.
Prof. Dr. Kathleen M. Mulder
Guest Editor
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Keywords
- Ras
- Rab
- Ras/Rab protein complexes
- trafficking
- signaling
- motor proteins
- neurodegenerative diseases
- cancer
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