Gastro-Entero-Pancreatic Neuroendocrine Tumors: From Challenges in Basic Science to Controversies in Clinical Practice
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 3795
Special Issue Editors
Interests: gastroenterology; inflammatory bowel diseases; hepatology; neuroendocrine tumors
Special Issues, Collections and Topics in MDPI journals
Interests: gastroenterology; inflammatory bowel diseases; hepatology; neuroendocrine tumors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroendocrine tumors (NETs) are heterogeneous neoplasms that originate from the neuroendocrine cells of the diffuse endocrine system scattered throughout the entire body. The molecular mechanisms involved in their carcinogenesis are still far from being understood.
Recent genome-wide sequencing efforts have given important and innovative information on the molecular landscape of NETs. Some molecular mechanisms, such as chromatin remodeling and cell cycle control pathways, are described as major drivers of this disease. Moreover, the observed deregulation of Akt/mTOR pathways has been used to design targeted therapies that have proven efficacy in clinical trials.
Further progress in understanding the molecular mechanisms involved in NET carcinogenesis with their possible translational aspect and clinical applications represents an unmet need for planning tailored surgical or medical management of NET patients, as it could open important implications in the development of novel biology-based effective treatments.
This Special Issue aims to depict the recent advantages in the knowledge of the molecular aspects of gastrointestinal NETs, as well as their application in diagnosis, management and treatment of these tumors.
Prof. Dr. Pietro Invernizzi
Dr. Sara Massironi
Guest Editors
Manuscript Submission Information
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Keywords
- neuroendocrine tumors
- signal transduction pathways
- transcriptomes
- molecular biology
- precision medicine
