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The Role of Nutrition in Managing Neuroendocrine Neoplasms: Current Perspectives

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 1182

Special Issue Editors


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Guest Editor
1. Digestive Disease Unit, Sant’Andrea University Hospital, ENETS Center of Excellence or Rome, 00189 Rome, Italy
2. Department of Medical, Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy
Interests: neuroendocrine tumors; gastrointestinal disorders; pancreatic diseases; malnutrition
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Guest Editor
Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy
Interests: neuroendocrine tumors; endoscopic ultrasonography; pancreatic disorders; nutrition
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
European Neuroendocrine Tumor Society (ENETS) Center of Excellence, Digestive Disease Unit, Sant’Andrea University Hospital, 00189 Rome, Italy
Interests: pancreatic islet cell tumor; neuroendocrine tumor; pancreatic cancer

Special Issue Information

Dear Colleagues,

This Special Issue delves into the critical role that nutrition plays in managing neuroendocrine neoplasms (NENs), a heterogeneous group of rare tumors arising from neuroendocrine cells, which frequently present unique challenges due to their hormonal activity and varied anatomical locations. Recent advances in nutritional science have highlighted potential therapeutic strategies that can complement traditional treatments, such as surgery, systemic therapy, and radioligand therapy. Contributions to this Special Issue explore how nutritional status can influence the metabolic pathways involved in tumor growth and symptom management, offering new insights into patient care, focusing on the potential impact of nutritional status on response to treatments, patients' quality of life, and clinical outcomes.

Prof. Dr. Francesco Panzuto
Dr. Sara Massironi
Dr. Maria Rinzivillo
Guest Editors

Manuscript Submission Information

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Keywords

  • neuroendocrine tumors
  • nutritional status
  • survival
  • quality of life
  • treatment

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Published Papers (1 paper)

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Research

10 pages, 787 KiB  
Article
Sarcopenia in Patients with Advanced Gastrointestinal Well-Differentiated Neuroendocrine Tumors
by Elena Romano, Michela Polici, Matteo Marasco, Francesco Lerose, Elisabetta Dell’Unto, Stefano Nardacci, Marta Zerunian, Elsa Iannicelli, Maria Rinzivillo, Andrea Laghi, Bruno Annibale, Francesco Panzuto and Damiano Caruso
Nutrients 2024, 16(14), 2224; https://doi.org/10.3390/nu16142224 - 11 Jul 2024
Cited by 1 | Viewed by 969
Abstract
Background: Neuroendocrine neoplasms (NENs) are slow-growing tumors. Sarcopenia is defined as the loss of muscle mass, strength, and physical performance. First-line NEN therapy is somatostatin analogs, which could be responsible for malabsorption conditions, such as pancreatic exocrine insufficiency (EPI) with underlying sarcopenia. Aim: [...] Read more.
Background: Neuroendocrine neoplasms (NENs) are slow-growing tumors. Sarcopenia is defined as the loss of muscle mass, strength, and physical performance. First-line NEN therapy is somatostatin analogs, which could be responsible for malabsorption conditions, such as pancreatic exocrine insufficiency (EPI) with underlying sarcopenia. Aim: Evaluate the prevalence of sarcopenia in patients with NENs at diagnosis and during follow-up. Methods: A retrospective single-center study was conducted, including patients with advanced intestinal NENs G1/G2 (excluded pancreatic NENs). CT scans were analyzed at diagnosis and after 6 months of therapy, and the skeletal muscle index was assessed. Results: A total of 30 patients (F:M = 6:24) were enrolled, with the following primary tumor sites: 25 in the ileum, 1 stomach, 2 jejunum, and 2 duodenum. At diagnosis, 20 patients (66.6%) showed sarcopenic SMI values, and 10 patients (33.3%) showed non-sarcopenic SMI values. At follow-up, three more patients developed sarcopenic SMI values. Statistical significance in relation to the presence of sarcopenia was found in the group of patients with carcinoid syndrome (p = 0.0178), EPI (p = 0.0018), and weight loss (p = 0.0001). Conclusion: Sarcopenia was present in 2/3 of the patients with advanced intestinal NENs at the diagnosis and during the follow-up. It is reasonable to consider this condition to improve clinical outcomes. Full article
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