The PTEN Tumor Suppressor and Its Role in Tumor Pathogenesis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 24533
Special Issue Editors
Interests: PTEN; PI3K; AKT; liver cancer; lipid metabolism; cancer stem cells; mitochondria
Special Issue Information
Dear Colleagues,
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein that has an N-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine–protein phosphatase auxilin. Since its discovery in 1997, PTEN has been identified to be the 2nd most commonly lost tumor suppressor in primary malignancies. Alterations including point mutations, deletions, and genomic rearrangements of PTEN have been identified in numerous cancers. Epigenetic modifications, promotor methylation and microRNAs that target PTEN have also been identified that play important roles in regulating PTEN in tumors. Germline deletion of PTEN is found in familial syndromes such as Cowden’s and Bannayan–Riley–Ruvalcaba (BRR), now collectively termed PHTS (PTEN hamartoma tumor syndrome). Patients with PHTS are prone to develop multiple tumors in their life time due to loss of PTEN function. On the molecular level, PTEN regulates a variety of cellular processes via its phosphatase function including its primary target, the PI3K/AKT signaling pathway. In this Special Issue of Cells, titled “The PTEN Tumor Suppressor and Its Role in Tumour Pathogenesis”, we would like to welcome original research and review articles that focus on the role of PTEN in tumor development; explore the pathogenesis of PTEN regulated tumorigenesis; explore past and ongoing efforts to target PTEN regulated signals in tumor development; and provide perspectives on future directions in PTEN research and drug development.
Prof. Bangyan L. StilesDr. Reginald Hill
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- PTEN
- PI3K
- AKT
- mTOR
- tumor
- metabolism
- PHTS
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.