Giant Cell Arteritis
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (1 November 2023) | Viewed by 160
Special Issue Editor
Interests: understanding inflammatory fibrosis in order to develop new treatments
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Giant cell arteritis (also called temporal arteritis, GCA) is a significant and highly prevalent large vessel vasculitis affecting elderly Caucasian populations. Various clinical manifestations include headaches of varying severity and location, jaw claudication through the ischaemia of masseters, cervical and brainstem features through vertebra-basilar involvement, and visual loss, which can be permanent and bilateral. Due to this latter complication, GCA carries the highest medicolegal cost burden for both primary care and rheumatology specialists. Various models have been proposed to account for the disease, including immunogenetic background, ageing, and environmental damage to the cranial arteries followed by innate and adaptive cellular infiltration from the adventitia to the internal elastic lamina of affected cranial arteries. Advances in imaging include using FDG-PET scanning to show a characteristic aortic arch and subclavian pattern and using ultrasound imaging to reveal the halo sign around affected temporal arteries. Tissue sampling of the temporal artery remains the gold standard for diagnosis on which to base therapies such as high-dose steroids, synergising DMARDs, and more recently introduced biologics, such as IL-6 pathway inhibitors. However, this condition remains challenging to diagnose with certainty and treat without causing significant off-target effects.
Dr. Richard Stratton
Guest Editor
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Keywords
- large vessel vasculitis
- aging
- macrophage
