Cardiomyopathy: Pathogenesis, Diagnosis, and Treatment

Dear Colleagues,

Heart muscle disease, a leading cause of death worldwide, is etiologically and phenotypically heterogeneous and is caused by a combination of genetic and non-genetic factors. Cardiomyopathies are defined as myocardial disorders in which the heart is structurally or/and functionally abnormal. Recent progress in elucidating molecular, cellular and physiological mechanisms has promoted new concepts that have inspired more effective treatment strategies. This special issue on Cardiomyopathies Pathogenesis, Diagnosis, and Treatment will focus on the fundamental mechanisms that drive genetic and SARS-Cov2 induced cardiomyopathies, with the main goal of uncovering novel pathways and targets to predict the development of the disease and to protect or restore cardiac function. The topics included in the issue will cover the latest advances in dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), channelopathies, and derived complications of SARS-Cov2. Manuscript should pay special attention to key scientific discoveries, relevant to both basic and clinical research, emphasizing advances in molecular and structural biology, omics, stem cell research, electrophysiology, high-resolution imaging and disease modeling to understand the mechanistic nature of cardiac dysfunction in these conditions. The especial issue on “Cardiomyopathy: Pathogenesis, Diagnosis, and Treatment” seeks to provide a comprehensive understanding of the epidemiology, underlying mechanisms, natural course and recent therapeutic advances that can have an impact on the management and prognosis of patients with complex cardiomyopathies.

Dr. Juan A. Bernal
Guest Editor

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