Smoking and Lung Cancer: Cellular and Molecular Differences between Smokers and Never-Smokers
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1982
Special Issue Editors
Interests: flow cytometry; genetics; immunology; genotyping; autoimmune disease; HLA; MHC; lymphocytes; cells; biomedical science; single nucleotide polymorphism; natural killer; T lymphocytes; cancer; antigen-presenting machinery genes and molecules
Interests: cancer biology; cell proliferation; cancer biomarkers; tumor microenvironment; immunohistochemistry; histology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Smoking is a major risk factor for lung cancer, therefore lung cancer epidemiologic trends reflect the past trends of cigarette smoking to a great extent. Although lung cancer is strongly associated with cigarette smoking, nevertheless only about 15% of smokers get lung cancer, and also some never-smokers develop this malignancy. The proportion of never-smokers among Asian patients is higher than in Caucasians. Other environmental factors include air pollution: occupational; second-hand tobacco smoke; smog; cooking oil fumes, particularly in Asian women; smoke from domestic combustion for heating; and radon in uranium miners. Gender differences in prevalence and histology of lung cancer were observed, which may be explained by differences in lifestyle (including smoking behavior) and occupation as well as by a double dose of X chromosome containing the largest number of immune-related genes and micro-RNAs. There are significant histopathological differences between smokers and never-smokers. Expression of many genes is different in smoking versus never-smoking lung cancer patients. Polymorphisms of several genes have been found to be risk factors in never or light smokers but tended to be protective in heavy smokers. There are also differences in de novo gene mutations and their frequencies in smokers and never-smokers bearing lung cancer.
Prof. Dr. Piotr Kusnierczyk
Prof. Dr. Piotr Dzięgiel
Guest Editors
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Keywords
- lung cancer
- smokers versus never-smokers
- histology
- metabolism
- genetics
