Feature Papers in "Stem Cells" 2023
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 12147
Special Issue Editors
Interests: mesenchymal stem cells (MSC); MSC potentiation; MSC scale-up; regenerative medicine; immunomodulation; MSC signaling; clinical and translational research; process development
Interests: mesenchymal stem cell (MSC) biology; 3D-cell culture; microbiology; immunology; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells hold great promise for future cell replacement therapies, with each having its pros and cons. The development of these stem cells requires in-depth knowledge in understanding and controlling the mechanisms of stem cell maintenance and exit from the undifferentiated state in specific biomaterials that mimick in vivo niches. When grown in 3D, ESCs or iPSCs can recapitulate embryonic development as blastoids or organoids do, making them ideal for drug screening and genetic disease modeling. Although cells of the inner cell mass are in a transient state in the embryo and last just for a few days, it has been possible to capture their pluripotent fate in vitro. Indeed, they can be grown as cell lines indefinitely thanks to deep insights in the fundamental knowledge of their physiology. Adult stem cells on the other hand last throughout our entire life in specific physiological niches in our body but can typically be cultured in vitro only through limited number of population doublings. In this Special issue of Cells, we will gather articles and reviews on recent fundamental and applied advances on ESC, iPSCs, and adult stem cells.
Dr. Nisha C. Durand
Dr. Joni H. Ylostalo
Guest Editors
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