Molecular and Genetic Pathogenesis of Hematological Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 10 May 2025 | Viewed by 146
Special Issue Editors
2. Department of Laboratory Hematology, Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada
Interests: myeloma; molecular cytogenetics; prognostic factors; small molecule inhibitors
Special Issue Information
Dear Colleagues,
Hematological disorders, including leukemias, lymphomas, myelomas, anemias, and clotting disorders, account for a significant portion of the global disease burden, with hematologic malignancies alone constituting approximately 10% of new cancer diagnoses in 2023.
Understanding the molecular and genetic mechanisms underlying these disorders is crucial for developing targeted therapies. Recent advancements have highlighted the genetic mutations, epigenetic modifications, and molecular pathways driving these diseases. Breakthroughs in gene editing technologies, such as CRISPR/Cas9, have revolutionized our ability to identify and modify genetic aberrations. Additionally, insights into signal transduction pathways and the role of the microenvironment have deepened our understanding of disease progression and therapeutic resistance.
This Special Issue compiles original research and reviews on novel genetic biomarkers, innovative therapeutic strategies, and mechanisms of treatment resistance. By bringing together pioneering research, this Special Issue aims to advance our understanding and treatment of hematological disorders, ultimately improving patient outcomes.
Dr. Hong Chang
Dr. Deepak Narayanan Iyer
Guest Editors
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Keywords
- hematological disorders
- molecular and genetic mechanisms
- signal transduction pathways
- microenvironment
- gene editing technologies
- targeted therapies
- novel biomarkers
- mechanisms of treatment resistance
- innovative therapeutic strategies
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