Novel Insights into Molecular Mechanisms and Therapy of Soft Tissue Sarcomas

Dear Colleagues,

Soft tissue sarcomas (STSs) represent a cluster of uncommon malignant neoplasms originating from embryonic mesenchymal tissues that give rise to cartilage, muscle, blood vessels, nerves, and adipose tissue. More than 50 distinct subcategories of STSs have been identified, with certain subtypes showing a predilection for affecting children, while others predominantly affect adults. STSs exhibit substantial diversity at the cellular and genomic levels, encompassing subgroups primarily distinguished by chromosomal translocations or genetic anomalies, along with others characterized by limited genomic deviations.

In spite of recent advancements in therapeutic strategies, achieving effective local control of tumors in aggressive forms remains challenging, and the prognosis for patients with metastatic disease remains unfavorable. However, certain cutting-edge technologies have enabled the comprehensive identification of molecular mechanisms associated with different STS subtypes. Altered molecular mechanisms influenced by transcriptional, post-transcriptional or post-translational regulators have been implicated in crucial biological pathways in STSs. The identification of dysregulations at the molecular levels that confer vulnerabilities to therapeutic interventions is yielding new biomarkers and therapeutic targets, offering the potential to enhance clinical management.

This Special Issue invites submissions of high-quality original research and review articles centered on fundamental and translational research that shares insights on regulatory networks in both adult and pediatric STSs, and unveil novel mechanisms underpinning the pathogenesis and progression of STSs, ultimately offering novel avenues to enhance patient outcomes, particularly with regard to radiotherapy and drug resistance.

Dr. Matteo Cassandri
Dr. Silvia Pomella
Guest Editors

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