Autophagy Genes—Biological Functions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 5949
Special Issue Editors
Interests: vascular biology; angiogenesis; cell signaling; angiopoietins; tyrosine kinase receptors; endothelium; cell proliferation; cell differentiation; micro-RNAs; long noncoding RNAs
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondrial dynamics and mitophagy; muscle physiology; sarcopenia; mitochondrial biology
Special Issue Information
Dear Colleagues,
Autophagy is a process through which damaged or unnecessary cellular components are degraded by lysosomes. A specific form of autophagy, macroautophagy, is characterized by the formation of double-membrane vesicles that surround organelles, portions of cytoplasm, glycogen, and protein aggregates and deliver them to the lysosomes for degradation. Autophagy generally plays a critical pro-survival role in cellular homeostasis by removing accumulated debris and by regulating adaptation to metabolic stress. However, under specific conditions, autophagy may trigger cell death and promote cancer progression. Autophagy-related (ATG) proteins are required throughout the multiple stages of autophagosome formation in “canonical” autophagy, including initiation and nucleation of isolation membrane, elongation, autophagosome closure around the cargo, autophagosome docking and fusion with the lysosome, and degradation of the cargo by lysosomal enzymes. ATG proteins were first identified in yeast and are well-conserved across organisms. Recent studies have revealed that they are also involved in “non-canonical” functions that do not involve classical autophagosome formation or do not terminate with autophagosome-lysosome fusion. These functions are critical to host–pathogen interactions and immune signaling. This Special Issue will address various biological functions of several different autophagy-related genes in relation to normal cellular physiology and the pathophysiology of human disease.
Prof. Dr. Sabah Hussain
Dr. Gilles Gouspillou
Dr. Jean-Philippe Leduc-Gaudet
Guest Editors
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Keywords
- infection
- Autophagy Genes
- Cell Death
- metabolism
- neurodegenerative diseases
- skeletal muscle
- vesicular trafficking
- proliferation
- phagocytosis
- exocytosis
- inflammation
- cell survival
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