Cellular Reprogramming in Translational Research and Medicine
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 703
Special Issue Editor
Interests: stem cells; cellular reprogramming; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular reprogramming, including stem/progenitor cells and other functionally defined therapeutic cells, hold tremendous promise for patients with organ failure, as well as for diseases and disorders that cannot be cured by currently available medications. This biomanufacturing strategy is based on easily accessible and readily expandable cell sources that can provide desirable properties required for a given disease, i.e., tissue regeneration or paracrine actions. During the past decade, substantial advances have been made in differentiating human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), into specific lineage cells; however, these approaches raise the potential risk of tumorigenesis and ethical concerns, thus restricting their clinical applications. Accordingly, trans-differentiation of a functional cell type into another lineage, bypassing the pluripotent stage, can provide powerful benefits for clinical use in a tissue- and patient-specific manner. Nonetheless, challenges for large-scale, cost-effective, reproducible production of high-quality cells and strategies for maximizing their therapeutic performance must be addressed before clinical trials are conducted. In this context, recent progress in manipulating cell fates employing various sets of reprogramming factors and bioactive molecules show substantial improvements in efficiency, safety, reproducibility, and therapeutic feasibility in vivo.
The aim of this Special Issue is to publish original research articles in novel reprogramming technologies, understanding of the underlying mechanisms governing cellular reprogramming and its potential for translational medicine. Review articles critically and systematically covering the related researches, providing concluding remarks and future outlook in the field and highlighting their broad applicability in cellular reprogramming and its translational medicine will be considered for inclusion in this Special Issue.
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cellular reprogramming
- stem/progenitor cells
- cell therapy
- cell transplantation
- preclinical assessment
- regenerative medicine
- translational medicine
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