Biology of the Renin–Angiotensin Systems: Molecular to Systems Scale

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 4814

Special Issue Editor


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Guest Editor
Geisinger Commonwealth School of Medicine, Scranton, PA, USA
Interests: neural control of blood pressure; hypertension; neural actions of angiotensin II; medical education; medical school curricula

Special Issue Information

Dear Colleagues,

Cells, an open access journal, plans to publish a Special Issue on the renin–angiotensin system (RAS) highlighting advances which have led to our current understanding of this field in clinical medicine. The Special Issue will focus on recent findings in molecular genetics and biology, cell biology, and systems biology as they pertain to various facets of the RAS in health and disease. Manuscripts which either review work in these areas or report the findings of specific research projects will be considered for peer review. The deadline for submissions is 31 October 2019.

Dr. David B. Averill
Guest Editor

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Keywords

  • genomics
  • molecular biology
  • cell biology
  • systems biology
  • angiotensin peptides
  • tissue renin–angiotensin systems

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Published Papers (1 paper)

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Research

23 pages, 3862 KiB  
Article
Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular–Subventricular Zone
by Maria Garcia-Garrote, Ana Perez-Villalba, Pablo Garrido-Gil, German Belenguer, Juan A. Parga, Francisco Perez-Sanchez, Jose Luis Labandeira-Garcia, Isabel Fariñas and Jannette Rodriguez-Pallares
Cells 2019, 8(12), 1551; https://doi.org/10.3390/cells8121551 - 30 Nov 2019
Cited by 21 | Viewed by 4446
Abstract
The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have [...] Read more.
The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the role of major RAS receptors on neurogenesis in the V-SVZ of adult mice and rats. In mice, we showed that the increase in proliferation of cells in this neurogenic niche was induced by activation of AT2 receptors but depended partially on the AT2-dependent antagonism of AT1 receptor expression, which restricted proliferation. Furthermore, we observed a functional dependence of AT2 receptor actions on Mas receptors. In rats, where the levels of the AT1 relative to those of AT2 receptor are much lower, pharmacological inhibition of the AT1 receptor alone was sufficient in increasing AT2 receptor levels and proliferation in the V-SVZ. Our data revealed that interactions between RAS receptors play a major role in the regulation of V-SVZ neurogenesis, particularly in proliferation, generation of neuroblasts, and migration to the olfactory bulb, both in young and aged brains, and suggest potential beneficial effects of RAS modulators on neurogenesis. Full article
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